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General Information
Symbol
Dmel\Debcl22
Species
D. melanogaster
Name
FlyBase ID
FBal0285544
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The entire Debcl gene has been replaced by a w+mW.hs marker.

Insertion components
TI{TI}Debcl22
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

debcl22/debclKO-unspecified flies are viable, fertile and exhibit a normal lifespan.

At variable penetrance, extra scutellar bristles are found on the notum.

debcl22/debcl27 embryos have extra Kr-positive cells in segments A4 and A5 of the ventral nerve cord - these cells normally die.

debcl22 embryos have extra Kr-positive cells in Bolwig's organ - these cells normally die.

WT and debcl22 larval wing discs show comparable increases in ionizing radiation-induced cell death.

debcl22 animals are slightly compromised for viability after ionizing radiation challenge at the larval stage.

debcl22/debcl27 and debcl22/debcl61 animals show an increased frequency of notched wings after ionizing radiation challenge at the larval stage, compared to wild type.

WT and debcl22/debcl27 larval wing discs show comparable proliferative arrest and resumption of proliferation kinetics after ionizing radiation exposure.

debcl22 and debcl22/debcl59 animals show normal starvation-induced autophagy, and normal survival curves when transferred from fed to starved conditions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

Debcl22 is an enhancer of wing | progressive phenotype of DarkCD4

Additional Comments
Genetic Interactions
Statement
Reference

The incidence and severity of melanized wing blemishing is exacerbated in debcl22, ArkCD4 double mutants compared to ArkCD4 alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)