FlyBase Allele Report: Dmel\Debcl[61]

General Information

Symbol

Dmel\Debcl⁶¹

Species

D. melanogaster

Name

FlyBase ID

FBal0285550

Feature type

allele

Associated gene

Dmel\Debcl

Associated Insertion(s)

TI{TI}Debcl⁶¹

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Galindo et al., 2009)

Mutagen

ends-out gene targeting

(Galindo et al., 2009)

I-SceI

(Galindo et al., 2009)

FLPase

(Galindo et al., 2009)

Progenitor genotype

Associated Insertion(s)

TI{TI}Debcl⁶¹

Cytology

Description

The entire Debcl gene has been replaced by a w^+mW.hs marker.

(Galindo et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | embryonic stage (with Debcl⁵⁹)

(Galindo et al., 2009)

fertile (with Debcl^{KO-unspecified})

(Galindo et al., 2009)

radiation sensitive

(Galindo et al., 2009)

radiation sensitive (with Debcl²²)

(Galindo et al., 2009)

radiation sensitive (with Debcl⁵⁹)

(Galindo et al., 2009)

viable (with Debcl^{KO-unspecified})

(Galindo et al., 2009)

Phenotype Manifest In

larval ventral nerve cord | embryonic stage (with Debcl⁵⁹)

(Galindo et al., 2009)

wing margin | conditional (with Debcl²²)

(Galindo et al., 2009)

wing margin | conditional (with Debcl⁵⁹)

(Galindo et al., 2009)

Detailed Description

Statement

Reference

debcl⁶¹/debcl^{KO-unspecified} flies are viable, fertile and exhibit a normal lifespan.

debcl⁵⁹/debcl⁶¹ embryos have extra Kr-positive cells in segments A4 and A5 of the ventral nerve cord - these cells normally die.

debcl⁶¹ animals are slightly compromised for viability after ionizing radiation challenge at the larval stage.

debcl²²/debcl⁶¹ animals show an increased frequency of notched wings after ionizing radiation challenge at the larval stage, compared to wild type.

debcl⁵⁹/debcl⁶¹ animals show an increased frequency of notched wings after ionizing radiation challenge at the larval stage, compared to wild type.

(Galindo et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Debcl⁶¹

debcl⁶¹

(Galindo et al., 2009)

debcl^KO

(Galindo et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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