FlyBase Allele Report: Dmel\Debcl[59]

General Information

Symbol

Dmel\Debcl⁵⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0285549

Feature type

allele

Associated gene

Dmel\Debcl

Associated Insertion(s)

TI{TI}Debcl⁵⁹

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Galindo et al., 2009)

Mutagen

ends-out gene targeting

(Galindo et al., 2009)

I-SceI

(Galindo et al., 2009)

FLPase

(Galindo et al., 2009)

Progenitor genotype

Associated Insertion(s)

TI{TI}Debcl⁵⁹

Cytology

Description

The entire Debcl gene has been replaced by a w^+mW.hs marker.

(Galindo et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | embryonic stage

(Galindo et al., 2009)

decreased cell death | embryonic stage (with Debcl⁶¹)

(Galindo et al., 2009)

fertile (with Debcl^{KO-unspecified})

(Galindo et al., 2009)

radiation sensitive (with Debcl²⁷)

(Galindo et al., 2009)

radiation sensitive (with Debcl⁶¹)

(Galindo et al., 2009)

viable (with Debcl^{KO-unspecified})

(Galindo et al., 2009)

Phenotype Manifest In

Bolwig organ | embryonic stage

(Galindo et al., 2009)

larval ventral nerve cord | embryonic stage (with Debcl⁶¹)

(Galindo et al., 2009)

midline glial cell | embryonic stage | increased number

(Galindo et al., 2009)

wing margin | conditional (with Debcl²⁷)

(Galindo et al., 2009)

wing margin | conditional (with Debcl⁶¹)

(Galindo et al., 2009)

Detailed Description

Statement

Reference

debcl⁵⁹/debcl^{KO-unspecified} flies are viable, fertile and exhibit a normal lifespan.

debcl⁵⁹/debcl⁶¹ embryos have extra Kr-positive cells in segments A4 and A5 of the ventral nerve cord - these cells normally die.

debcl⁵⁹ embryos have extra Kr-positive cells in Bolwig's organ - these cells normally die.

debcl⁵⁹ embryos have extra sli-positive cells in midline glia - these cells normally die.

debcl²⁷/debcl⁵⁹ animals show an increased frequency of notched wings after ionizing radiation challenge at the larval stage, compared to wild type.

debcl⁵⁹/debcl⁶¹ animals show an increased frequency of notched wings after ionizing radiation challenge at the larval stage, compared to wild type.

debcl⁵⁹ eyes show normal gross patterning.

debcl⁵⁹ and debcl²²/debcl⁵⁹ animals show normal starvation-induced autophagy, and normal survival curves when transferred from fed to starved conditions.

(Galindo et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Debcl⁵⁹ is an enhancer of wing | progressive phenotype of Dark^CD4

(Galindo et al., 2009)

NOT Enhancer of

Statement

Reference

Debcl⁵⁹ is a non-enhancer of eye phenotype of rpr^GMR.PH

(Galindo et al., 2009)

Debcl⁵⁹ is a non-enhancer of eye phenotype of grim^GMR.PC

(Galindo et al., 2009)

Debcl⁵⁹ is a non-enhancer of eye phenotype of hid^GMR.PG

(Galindo et al., 2009)

NOT Suppressor of

Statement

Reference

Debcl⁵⁹ is a non-suppressor of eye phenotype of hid^GMR.PG

(Galindo et al., 2009)

Debcl⁵⁹ is a non-suppressor of eye phenotype of grim^GMR.PC

(Galindo et al., 2009)

Debcl⁵⁹ is a non-suppressor of eye phenotype of rpr^GMR.PH

(Galindo et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The incidence and severity of melanized wing blemishing is exacerbated in debcl⁵⁹, Ark^CD4 double mutants compared to Ark^CD4 alone.

(Galindo et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Debcl⁵⁹

debcl⁵⁹

(Galindo et al., 2009)

debcl^59c

(Galindo et al., 2009)

debcl^KO

(Galindo et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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