FlyBase Allele Report: Dmel\Debcl[JF02429]

General Information

Symbol

Dmel\Debcl^JF02429

Species

D. melanogaster

Name

FlyBase ID

FBal0220773

Feature type

allele

Associated gene

Dmel\Debcl

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02429}

Also Known As

UAS-Debcl RNAi, UAS-Debcl-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02429}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02429

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Debcl^JF02429 under the control of Scer\GAL4^Ddc.PL does not significantly alter the median adult lifespan relative to controls but it slightly improves their age-dependent climbing abilities. Expression under the Scer\GAL4^GMR.PF driver has no major effect on the adult eye morphology and number of ommatidia.

(M'Angale and Staveley, 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Debcl^JF02429, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Suppressor of

Statement

Reference

Debcl^JF02429, Scer\GAL4^esg.PU is a suppressor of hyperplasia | adult stage phenotype of Scer\GAL4^esg.PU, synr^{UAS.ORF.GW.Tag:HA}

(Sulekh et al., 2024)

Debcl^JF02429, Scer\GAL4^nub-AC-62 is a suppressor of visible | adult stage phenotype of Scer\GAL4^nub-AC-62, synr^{UAS.ORF.GW.Tag:HA}

(Ikegawa et al., 2023)

Debcl^JF02429, Scer\GAL4^Ddc.PL is a suppressor of short lived phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^JF02429, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Debcl^JF02429, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

NOT Suppressor of

Statement

Reference

Debcl^JF02429, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Debcl^JF02429, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Suppressor of

Statement

Reference

Debcl^JF02429, Scer\GAL4^esg.PU is a suppressor of adult gut phenotype of Scer\GAL4^esg.PU, synr^{UAS.ORF.GW.Tag:HA}

(Sulekh et al., 2024)

Debcl^JF02429, Scer\GAL4^nub-AC-62 is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, synr^{UAS.ORF.GW.Tag:HA}

(Ikegawa et al., 2023)

Debcl^JF02429, Scer\GAL4^GMR.PF is a suppressor of eye | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Debcl^JF02429, Scer\GAL4^GMR.PF is a suppressor of ommatidium | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

NOT Suppressor of

Statement

Reference

Debcl^JF02429, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The morphology and number of ommatidia in the eyes of adult flies expressing both Debcl^JF02429 and Buffy^Scer\UAS.cQa simultaneously under the control of Scer\GAL4^GMR.PF is comparable to controls.

(M'Angale and Staveley, 2016)

Xenogenetic Interactions

Statement

Reference

The reduced adult lifespan and poor climbing ability characteristic for adult flies expressing Hsap\SNCA^Scer\UAS.cFa (with the Scer\GAL4^Ddc.PL driver) as well as the morphological eye defects and ommatidial disarray (using the Scer\GAL4^GMR.PF driver) are significantly improved by co-expression of Debcl^JF02429 RNAi.

(M'Angale and Staveley, 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27083

y¹ v¹; P{TRiP.JF02429}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Debcl^JF02429

debcl^JF02429

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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