FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DebclUAS.Tag:HA
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General Information
Symbol
Dmel\DebclUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0103854
Feature type
allele
Associated gene
Dmel\Debcl
Associated Insertion(s)
Carried in Construct
P{UAS-Debcl.HA}
Also Known As
UAS-debcl
Key Links
Transgenic product class
cDNA
(Colussi et al., 2000)
wild_type
(Colussi et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Colussi et al., 2000)
wild_type
(Colussi et al., 2000)
Mutagen
in vitro construct
(Colussi et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Debcl.HA}
Cytology
Description

UASt regulatory sequences drive expression of a Debcl cDNA tagged at the N-terminal end with Tag:HA.

(Colussi et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Debcl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Ddc.PL results in significantly reduced median adult lifespan as well as decrease in age-dependent climbing abilities compared to controls. Expression under the Scer\GAL4GMR.PF driver leads to severely disrupted adult eye morphology and loss of ommatidia.

      (M'Angale and Staveley, 2016)

      Expression of DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc.PU results in an increase in the apoptosis in the antero-posterior frontier of the third instar wing disc, and adult wings exhibit a reduction in the distance between the L3 and L4 wing veins in the proximal region of the wing, and a fusion of these veins at the anterior crossvein, as compared to wild type.

      (Colin et al., 2014)

      Expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in a small eye phenotype. Eye discs of these animals show increased apoptosis compared to controls.

      (Park et al., 2010)

      Flies expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Uro.PT show similar survival to wild-type flies under H[[2]]O[[2]]-induced oxidative stress.

      (Terhzaz et al., 2010)

      Expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ppk.1.9 in ddaC neuron clones results in smaller, simpler dendritic arbors and also in breakage of proximal branches of the arbor.

      The density of mitochondria (assayed by the expression of markers with a mitochondrial targeting signal) is significantly reduced in neuronal processes of ddaC neurons expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ppk.1.9 compared to controls.

      Class IV v'ada neurons in the adult abdomen that are expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ppk.1.9 show a significant reduction in the total length of dendritic branches compared to controls.

      (Tsubouchi et al., 2009)

      Expression of the debcldsRNA.Scer\UAS transgene completely blocks the small-eye phenotype caused by debclScer\UAS.T:Ivir\HA1 overexpression (under the control of Scer\GAL4GMR.PF).

      (Senoo-Matsuda et al., 2005)

      When debclScer\UAS.T:Ivir\HA1 is driven by Scer\GAL4GMR.PF a strong ablated eye phenotype is seen. When driven by Scer\GAL4en-e16E an ablated wing phenotype is seen.

      (Quinn et al., 2003)

      Heat shock induced expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB results in enhanced levels of cell death in the embryos and in larval tissues. Expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in increased cell death in the posterior region of the eye disc. Adult flies have severely ablated, rough eyes and patches of reduced pigmentation. Expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ey.PH results in increased cell death in the anterior and posterior regions of the eye disc. Expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109-88 results in increased cell death and a reduction in size of the salivary glands.

      (Colussi et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      DebclUAS.Tag:HA, Scer\GAL4ptc.PU has visible | adult stage phenotype, non-enhanceable by morgueEP1184

      (Colin et al., 2014)
      Suppressed by
      NOT suppressed by
      Enhancer of
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      DebclUAS.Tag:HA, Scer\GAL4ptc.PU has wing | adult stage phenotype, non-enhanceable by morgueEP1184

      (Colin et al., 2014)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      DebclUAS.Tag:HA, Scer\GAL4ptc.PU has wing | adult stage phenotype, non-suppressible by Uba1UY3010, Scer\GAL4ptc.PU

      (Colin et al., 2014)

      DebclUAS.Tag:HA, Scer\GAL4ptc.PU has wing | adult stage phenotype, non-suppressible by morgueEP1184

      (Colin et al., 2014)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by porinA2/porinA2

      (Park et al., 2010)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye disc phenotype, non-suppressible by porinA2/porinA2

      (Park et al., 2010)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by porin[+]/porinA2

      (Park et al., 2010)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye disc phenotype, non-suppressible by porin[+]/porinA2

      (Park et al., 2010)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3L)H99

      (Colussi et al., 2000)

      DebclUAS.Tag:HA, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(2R)Jp1

      (Colussi et al., 2000)
      Enhancer of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The shortened lifespan and poor climbing ability characteristic for adult flies expressing DebclScer\UAS.T:Ivir\HA1 (with the Scer\GAL4Ddc.PL driver) as well as the eye morphological defects and loss of ommatidia (using the Scer\GAL4GMR.PF driver) is much improved by co-expression of BuffyScer\UAS.cQa.

      (M'Angale and Staveley, 2016)

      Co-expression of Uba1EP2375, but not Uba1UY3010, almost completely suppresses the adult wing phenotype of flies expressing DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc.PU.

      Rpn10Pw+ partially suppresses the adult wing phenotype of flies expressing DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc.PU.

      The presence of Prosα2EP931 or slmb41 enhances the adult wing phenotype of flies expressing DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc.PU.

      The presence of morgueEP1184 does not significantly affect the adult wing phenotype of flies expressing DebclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc.PU.

      (Colin et al., 2014)

      porinA2/+ or porinA2/porinA2 does not suppress the small eye phenotype seen in animals expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF. The increased apoptosis seen in the eye discs of these animals is also not suppressed by either porinA2/+ or porinA2/porinA2.

      (Park et al., 2010)

      Co-expression of BuffyScer\UAS.cQa suppresses the mutant phenotype that is seen in the dendritic arbor of ddaC neuron clones expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ppk.1.9.

      Co-expression of BuffyScer\UAS.cQa suppresses the altered mitochondrial distribution seen in ddaC neurons expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ppk.1.9.

      (Tsubouchi et al., 2009)

      The eye phenotype caused by expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF is significantly suppressed by ArkCD8 but is not significantly suppressed by Df(3L)H99 or Df(2R)Jp1. The eye phenotype is enhanced by Df(3L)brm11 or Df(3L)st-f13.

      (Colussi et al., 2000)

      The eye phenotype caused by expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF is significantly suppressed by BacA\p35GMR.PH or ArkCD8 but is not significantly suppressed by Df(3L)H99 or Df(2R)Jp1. The eye phenotype is enhanced by Df(3L)brm11 or Df(3L)st-f13.

      (Colussi et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference

      The reduced adult lifespan and poor climbing ability characteristic for adult flies expressing Hsap\SNCAScer\UAS.cFa (with the Scer\GAL4Ddc.PL driver) as well as the morphological eye defects and ommatidial disarray (using the Scer\GAL4GMR.PF driver) are further worsened by co-expression of DebclScer\UAS.T:Ivir\HA1.

      (M'Angale and Staveley, 2016)

      The eye phenotype caused by expression of debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF is significantly suppressed by BacA\p35GMR.PH.

      (Colussi et al., 2000)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DebclScer\UAS.T:Ivir\HA1
      DebclUAS.Tag:HA
      debclScer\UAS.T:Ivir\HA1
      Name Synonyms
      Secondary FlyBase IDs
        References (11)