FlyBase Allele Report: Dmel\Uba1[EP2375]

General Information

Symbol

Dmel\Uba1^EP2375

Species

D. melanogaster

Name

FlyBase ID

FBal0119371

Feature type

allele

Associated gene

Dmel\Uba1

Associated Insertion(s)

P{EP}Uba1^EP2375

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Wing et al., 2002, Gene Disruption Project members, 2001-, Misra, 2000.11.18)

Progenitor genotype

Associated Insertion(s)

P{EP}Uba1^EP2375

Cytology

Description

P{EP} insertion in Uba1.

(Misra, 2000.11.18)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:9,692,764..9,692,764 [-]

(Wing et al., 2002, Gene Disruption Project members, 2001-, Misra, 2000.11.18)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Uba1^EP2375 under the control of Scer\GAL4^vg.PM or Scer\GAL4^ptc.PU does not lead to any apparent wing phenotype.

(Colin et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/Uba1^EP2375 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Suppressor of

Statement

Reference

Uba1^EP2375, Scer\GAL4^ptc.PU is a suppressor | partially of visible | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

Uba1^EP2375, Scer\GAL4^vg.PM is a suppressor of visible | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Uba1^EP2375, Scer\GAL4^vg.PM is a suppressor of increased cell death | third instar larval stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Uba1^EP2375, Scer\GAL4^da.G32 is a suppressor of lethal - all die during embryonic stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^da.G32

(Colin et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/Uba1^EP2375 is an enhancer of pigment cell phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Suppressor of

Statement

Reference

Uba1^EP2375, Scer\GAL4^ptc.PU is a suppressor | partially of wing | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

Uba1^EP2375, Scer\GAL4^vg.PM is a suppressor of wing | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Uba1^EP2375, Scer\GAL4^vg.PM is a suppressor of wing disc | third instar larval stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Uba1^EP2375 almost completely suppresses the adult wing phenotype of flies expressing Debcl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ptc.PU.

(Colin et al., 2014)

Co-expression of Uba1^EP2375 enhances the eye phenotype caused by expression of grim::rpr^rg.Scer\UAS under the control of Scer\GAL4^GMR.PF; eye pigmentation is reduced.

(Wing et al., 2002)

Xenogenetic Interactions

Statement

Reference

Co-expression of Uba1^EP2375 almost completely suppresses the notched wing phenotype observed in adults, and reduces the number of apoptotic cells in third instar wing discs in flies expressing Mmus\Bax^Scer\UAS.cGa under the control of Scer\GAL4^vg.PM.

Co-expression of Uba1^EP2375 partially rescues the lethality seen in flies expressing Mmus\Bax^Scer\UAS.cGa under the control of Scer\GAL4^da.G32.

(Colin et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP(2)2375

(Misra, 2000.11.18)

Uba1^EP2375

(Colin et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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