FlyBase Allele Report: Dmel\wls[1]

General Information

Symbol

Dmel\wls¹

Species

D. melanogaster

Name

FlyBase ID

FBal0194734

Feature type

allele

Associated gene

Dmel\wls

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Banziger et al., 2006)

Progenitor genotype

Cytology

Description

Contains a 47bp deletion that leads to a frameshift close to the end of the signal sequence (amino acid residue 29).

(Banziger et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:11,169,315..11,169,361 [-]

Comment:

Approximate boundaries of 47bp deletion that causes a frameshift at amino acid residue 29. Position of deletion on reference sequence inferred by FlyBase curator.

(Banziger et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with wls²), with Scer\GAL4^wg-ND382, wls^UAS.Tag:HA

(Banziger et al., 2006)

female sterile (with wls²), with Scer\GAL4^wg-S180, wls^UAS.Tag:HA

(Banziger et al., 2006)

lethal

(Gasnereau et al., 2011)

lethal - all die before end of P-stage (with wls²)

(Banziger et al., 2006)

male sterile (with wls²), with Scer\GAL4^wg-ND382, wls^UAS.Tag:HA

(Banziger et al., 2006)

male sterile (with wls²), with Scer\GAL4^wg-S180, wls^UAS.Tag:HA

(Banziger et al., 2006)

some die during pharate adult stage (with wls²)

(Banziger et al., 2006)

visible | homeotic (with wls²)

(Banziger et al., 2006)

Phenotype Manifest In

adult antennal segment (with wls²)

(Banziger et al., 2006)

arista (with wls²)

(Banziger et al., 2006)

leg (with wls²)

(Banziger et al., 2006)

mesonotum (with wls²)

(Banziger et al., 2006)

ovary (with wls²), with Scer\GAL4^wg-ND382, wls^UAS.Tag:HA

(Banziger et al., 2006)

ovary (with wls²), with Scer\GAL4^wg-S180, wls^UAS.Tag:HA

(Banziger et al., 2006)

testis (with wls²), with Scer\GAL4^wg-ND382, wls^UAS.Tag:HA

(Banziger et al., 2006)

testis (with wls²), with Scer\GAL4^wg-S180, wls^UAS.Tag:HA

(Banziger et al., 2006)

wing, with wls^t.AEGL

(Gasnereau et al., 2011)

wing (with wls²)

(Banziger et al., 2006)

wing margin, with wls^t.AEGL

(Gasnereau et al., 2011)

wing margin | somatic clone (with wls²)

(Banziger et al., 2006)

wing margin bristle, with wls^t.AEGL

(Gasnereau et al., 2011)

Detailed Description

Statement

Reference

100% of wls¹ flies rescued by the presence of the wls^t.AEGL transgene, display a wing phenotype and a reduced number of bristles at the anterior wing margin. In contrast, wls¹ mutant flies rescued by the presence of wls^+tGa appear wild-type.

(Gasnereau et al., 2011)

srt¹/srt² pharate adults (the stage at which these mutants die) exhibit rudimentary legs, lack arista and antennal segments and show wing-to-notum transformations.

srt¹/srt² mutant clones cause nicks at the margin of the wing blade.

srt¹/srt² flies rescued by expression of srt^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^wg-ND382 or Scer\GAL4^wg-S180 exhibit testicular and ovarian phenotypes as well as male and female sterility.

(Banziger et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

wls¹/wls¹ is a suppressor of ommatidium phenotype of wg^hs.2sev

(Banziger et al., 2006)

wls¹/wls¹ is a suppressor of interommatidial bristle phenotype of wg^hs.2sev

(Banziger et al., 2006)

wls¹/wls¹ is a suppressor of eye phenotype of wg^hs.2sev

(Banziger et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Mosaic animals in which most cells in the eye have a srt¹ genotype show a significant reversion of the rough eye phenotype seen when following expression of the wg^hs.2sev transgene.

(Banziger et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

wls²

(Banziger et al., 2006)

Rescued by

wls¹ is rescued by wls^+tGa

(Gasnereau et al., 2011)

wls¹ is rescued by wls^αTub84B.PB

(Banziger et al., 2006)

Partially rescued by

wls¹ is partially rescued by wls^t.AEGL

(Gasnereau et al., 2011)

wls²/wls¹ is partially rescued by wls^UAS.Tag:HA/Scer\GAL4^wg-ND382

(Banziger et al., 2006)

wls²/wls¹ is partially rescued by wls^UAS.Tag:HA/Scer\GAL4^wg-S180

(Banziger et al., 2006)

Comments

wls¹ mutant flies rescued by the presence of wls^+tGa appear wild-type.

(Gasnereau et al., 2011)

Expression of srt^{Scer\UAS.T:Ivir\HA1}, under the control of either Scer\GAL4^wg-ND382 or Scer\GAL4^wg-S180, rescues >80% of srt¹/srt² mutants to be viable adults.

(Banziger et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a repressor of the rough eye phenotype caused by expression of the wg^hs.2sev transgene.

(Banziger et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

srt¹

wls¹

(Herr and Basler, 2012, Gasnereau et al., 2011, Port et al., 2008, Banziger et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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