FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\wlsevi-2
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General Information
Symbol
Dmel\wlsevi-2
Species
D. melanogaster
Name
FlyBase ID
FBal0194741
Feature type
allele
Associated gene
Dmel\wls
Associated Insertion(s)
Carried in Construct
Also Known As
evi2
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Bartscherer et al., 2006)
Mutagen
Delta2-3 transposase
(Bartscherer et al., 2006)
Progenitor genotype
wlsEY01593
(Bartscherer et al., 2006)
Cytology
Description

Imprecise excision of the P{EPgy2} element, which results in a 771bp deletion of the srt gene, including 627bp that encode the N-terminal 209 amino acid residues.

(Bartscherer et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:11,168,819..11,169,589 [-]
Comment:

771bp deletion resulting from the imprecise excision of P{EPgy2}wlsEY01593. Sequences removed include the first 627 bases of the coding sequence.

(Bartscherer et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wlsevi-2 homozygous larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

      (Huang et al., 2018)

      Less than 2% of srtevi-2 animals survive to late pupal stages. These survivors exhibit severe developmental defects such as the loss of legs and enlarged eyes.

      Mutants with both maternal and zygotic srtevi-2 transcripts die during embryogenesis and have a severe segment polarity phenotype.

      srtevi-2 mutants show no planar cell polarity phenotypes, as judged by normal notal bristle orientation the lack of effect of mutant clones in the wing.

      (Bartscherer et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      egh[+]/egh62d18, wlsevi-2 has abnormal neuroanatomy | larval stage phenotype

      (Huang et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wlsevi-2/+; egh62d18/+ double heterozygotes have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls, unlike either heterozygote alone.

      (Huang et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      evi2
      (Chaudhary et al., 2019, Huang et al., 2018, Beckett et al., 2013, Korkut et al., 2013, Koles et al., 2012, Bartscherer et al., 2006)
      srtevi-2
      wlsevi-2
      Name Synonyms
      Secondary FlyBase IDs
        References (6)