FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IKKεUAS.Tag:MYC
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General Information
Symbol
Dmel\IKKεUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0194837
Feature type
allele
Associated gene
Dmel\IKKε
Associated Insertion(s)
Carried in Construct
P{UAS-IKKε.MYC}
Key Links
Transgenic product class
cDNA
(Oshima, 2006)
wild_type
(Oshima, 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Oshima, 2006)
wild_type
(Oshima, 2006)
Mutagen
in vitro construct
(Oshima, 2006)
Progenitor genotype
Carried in construct
P{UAS-IKKε.MYC}
Cytology
Description

UAS regulatory sequences drive expression of IKKε, tagged at the C-terminus with Tag:MYC. The IKKε open reading frame corresponds to SD10041.

(Oshima, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
IKKε
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of IKKεScer\UAS.T:Hsap\MYC under the control of Scer\GAL4sca.PU (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in reduction in the number of sensory bristles, but the remaining bristles are morphologically normal, as compared to controls.

      (Otani et al., 2015)

      Mild overexpression of ik2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4neur-P72 (using the temperature sensitive Scer\GAL80ts.αTub84B allele to overcome early lethality) results in thin, tapered bristles.

      (Otani et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of IKKεScer\UAS.T:Hsap\MYC under the control of Scer\GAL4sca.PU partially suppresses the bristle defects seen in spn-F1/spn-F1 mutants.

      (Otani et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      IKKεUAS.Tag:MYC is rescued by Scer\GAL4sca.PU/IKKεNIG.2615R

      (Otani et al., 2015)
      Rescues

      IKKεUAS.Tag:MYC rescues IKKε1

      (Otani et al., 2015)
      Comments

      Expression of IKKεScer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.PU rescues the bristle defects seen in IKKε1 mutants.

      Co-expression of IKKεNIG.2615R rescues the bristle loss seen in flies expressing IKKεScer\UAS.T:Hsap\MYC under the control of Scer\GAL4sca.PU.

      (Otani et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IKKεScer\UAS.T:Hsap\MYC
      IKKεUAS.Tag:MYC
      ik2Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)