FB2026_02 , released June 18, 2026
Allele: Dmel\Sec6175
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General Information
Symbol
Dmel\Sec6175
Species
D. melanogaster
Name
FlyBase ID
FBal0195147
Feature type
allele
Associated gene
Dmel\Sec6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Beronja et al., 2005)
Mutagen
P-element activity
(Beronja et al., 2005)
Progenitor genotype
CthEP2021
(Beronja et al., 2005)
Caused by aberration
Df(2R)Sec6175
Cytology
Description

sec6175 is the product of an imprecise excision of P{EP}EP2021 that deletes 1720 bp of DNA upstream of the original P{EP}EP2021 insertion site, thus removing the DNA encoding the 455 carboxy-terminal amino acids of the sec6 protein.

(Beronja et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sec6175 mutant animals fail to grow as larvae and die at approximately 72 hours after egg laying.

      sec6175 hemizygous and homozygous animals show identical phenotypes.

      Follicles containing a sec6175 germ-line clone show no apparent defects during early stages. However, by stage 6-7, plasma membrane is undetectable between germ-line cells, ring canals collapse to a single clump within the germline cyst, and nuclei show an irregular arrangement. sec6175 mutant follicles are not observed past stage 7, suggesting that they degenerate.

      Eye development is abolished when sec6175 mutant clones are induced in the eye and wild type sister clones are ablated.

      (Beronja et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated as an imprecise excision of P{EP}EP2021.

      (Beronja et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sec6175
      sec6175
      (Beronja et al., 2005)
      sec6Δ175
      (Venken, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)