FlyBase Allele Report: Dmel\mir-278[mirvana-1]

General Information

Symbol

Dmel\mir-278^mirvana-1

Species

D. melanogaster

Name

FlyBase ID

FBal0195447

Feature type

allele

Associated gene

Dmel\mir-278

Associated Insertion(s)

P{EP.y⁺.H}mir-278^EPC610

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Nairz et al., 2006)

Progenitor genotype

P{EP.y⁺.H}mir-278^EPC610

(Nairz et al., 2006)

Associated Insertion(s)

P{EP.y⁺.H}mir-278^EPC610

Cytology

Description

Nucleotide substitution: U5A.

(Nairz et al., 2006)

The progenitor P{EP.y⁺.H}mir-278^EPC610 insertion is still present on the chromosome.

(Nairz et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EP.y⁺.H}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Nairz et al., 2006)

viable

(Nairz et al., 2006)

Phenotype Manifest In

interommatidial bristle

(Nairz et al., 2006)

ommatidial precursor cluster, with Scer\GAL4^GMR.PF

(Nairz et al., 2006)

ommatidium

(Nairz et al., 2006)

Detailed Description

Statement

Reference

mir-278^mirvana-1 flies show no overgrowth in the eye but have a mild rough eye phenotype.

Some ommatidial cells in eye discs expressing mir-278^mirvana-1 under the control of Scer\GAL4^GMR.PF appear larger than in wild-type discs.

mir-278^mirvana-1 flies have a normal lifespan and are normal in size and weight.

mir-278^mirvana-1 clones in they eye are not significantly smaller than wild-type clones.

(Nairz et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

mir-278^mirvana-1/Scer\GAL4^GMR.PF is a non-suppressor of abnormal size | adult stage phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-suppressor of abnormal size | adult stage phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/Scer\GAL4^GMR.PF is a non-suppressor of abnormal size | adult stage phenotype of grim^GMR.PC

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-suppressor of abnormal size | adult stage phenotype of grim^GMR.PC

(Nairz et al., 2006)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

mir-278^mirvana-1/mir-278^mirvana-1 is a non-enhancer of ommatidium phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/mir-278^mirvana-1 is a non-enhancer of interommatidial bristle phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-enhancer of ommatidium phenotype of grim^GMR.PC

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-enhancer of interommatidial bristle phenotype of grim^GMR.PC

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-enhancer of ommatidium phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/Df(2R)Exel7137 is a non-enhancer of interommatidial bristle phenotype of hid^GMR.PG

(Nairz et al., 2006)

mir-278^mirvana-1/mir-278^mirvana-1 is a non-enhancer of ommatidium phenotype of grim^GMR.PC

(Nairz et al., 2006)

mir-278^mirvana-1/mir-278^mirvana-1 is a non-enhancer of interommatidial bristle phenotype of grim^GMR.PC

(Nairz et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype of flies expressing either grim^GMR.PC or W^GMR.PG is not enhanced by a mir-278^mirvana-1 or a mir-278^mirvana-1/Df(2R)Exel7137 background.

(Nairz et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that produces progeny with normal eye appearance.

(Nairz et al., 2006)

Comments

This was the only mutant found in a screen of over 10,000 flies, indicating that the gene provides a small target for mutagenesis.

(Nairz et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mir-278^mirvana-1

mirvana¹

(Nairz et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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