FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\X11LRNAi.UAS
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General Information
Symbol
Dmel\X11LRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0195805
Feature type
allele
Associated gene
Dmel\X11L
Associated Insertion(s)
Carried in Construct
P{UAS-X11L.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Vishnu et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Vishnu et al., 2006)
Mutagen
in vitro construct
(Vishnu et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-X11L.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of X11L, which is separated by a w intron. The X11L inverted repeat corresponds to the sequences encoding amino acids 1--20 of the protein.

(Vishnu et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
X11L
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of X11LdsRNA.Scer\UAS (X11L RNAi), under the control of Scer\GAL4GMR.PF, results in adult eyes that the completely lack rhabdomeres and have only a very thin epithelium. The lamina neuropil in these flies is extremely thin. The distal medulla neuropil is present but shows indication of axonal degeneration.

      When one copy of X11LdsRNA.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF, some cell sorting within eye discs takes place but not all excess interommatidial cells are eliminated by apoptosis. When two copies of X11LdsRNA.Scer\UAS are expressed, sorting of interommatidial precursor cells does not take place and some ommatidia contain supernumerary cone cells or only one primary pigment cell.

      (Vishnu et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, X11LRNAi.UAS has ommatidial precursor cluster phenotype, enhanceable by rst6/rst[+]

      (Vishnu et al., 2006)
      Enhancer of
      Statement
      Reference

      Scer\GAL4MZ1369/X11LRNAi.UAS is an enhancer of ommatidial precursor cluster phenotype of rst6

      (Vishnu et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of one copy of X11LdsRNA.Scer\UAS, driven by Scer\GAL4GMR.PF, in a rst6/+ background leads to severe cell sorting defects in eye discs, similar to those seen in rst6 homozygotes.

      (Vishnu et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      dsRNA has been transfected into flies to study the phenotypic consequences of dsRNA interference (RNAi) of the X11L gene.

      (Vishnu et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      X11LRNAi.UAS
      X11LdsRNA.Scer\UAS
      X11LdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)