FB2026_02 , released June 18, 2026
Allele: Dmel\dj-1βC45A.UAS
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General Information
Symbol
Dmel\dj-1βC45A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0196590
Feature type
allele
Associated gene
Dmel\dj-1β
Associated Insertion(s)
Carried in Construct
P{UAS-dj-1β.C45A}
Key Links
Transgenic product class
missense_variant
(Meulener et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Meulener et al., 2006)
Mutagen
in vitro construct
(Meulener et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-dj-1β.C45A}
Cytology
Description

UASt regulatory sequences drive expression of the dj-1β coding sequence bearing a C45A mutation.

(Meulener et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dj-1β
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Hao et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/dj-1βC45A.UAS is a suppressor | partially of visible phenotype of Pink1B9

      (Hao et al., 2010)

      Scer\GAL4da.PU/dj-1βC45A.UAS is a suppressor of increased cell death | adult stage phenotype of Pink1B9

      (Hao et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of dj-1βC45A.Scer\UAS under the control of Scer\GAL4da.PU rescues the thoracic muscle apoptosis phenotype, and partially rescues the wing posture defect of Pink1B9/Pink1B9 mutants.

      (Hao et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      dj-1βC45A.UAS/Scer\GAL4da.G32 rescues dj-1βΔ93

      (Meulener et al., 2006)
      Comments

      Expression of dj-1βC45A.Scer\UAS under the control of Scer\GAL4da.G32 rescues the paraquat and hydrogen peroxide sensitivity of dj-1βΔ93 flies to the same extent as expression of dj-1βScer\UAS.cMa using the same driver.

      (Meulener et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dj-1βC45A.Scer\UAS
      dj-1βC45A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)