FlyBase Allele Report: Dmel\polo[UASp.cMa]

General Information

Symbol

Dmel\polo^UASp.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0197254

Feature type

allele

Associated gene

Dmel\polo

Associated Insertion(s)

Carried in Construct

P{UASp-polo.M}

Also Known As

UAS-polo

Key Links

Transgenic product class

wild_type

(Mirouse et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mirouse et al., 2006)

Mutagen

in vitro construct

(Mirouse et al., 2006)

Progenitor genotype

Carried in construct

P{UASp-polo.M}

Cytology

Description

UASp regulatory sequences drive expression of polo.

(Mirouse et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

polo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

germarium region 2a, with Scer\GAL4^unspecified

(Mirouse et al., 2006)

germarium region 2b, with Scer\GAL4^unspecified

(Mirouse et al., 2006)

Detailed Description

Statement

Reference

Expression of polo^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^da.G32 has no effect on centrosome numbers or mitotic progression in larval brain neuroblasts.

(Martins et al., 2009)

Expression of polo^{Scer\UAS.P\T.cMa} in the female germline under the control of Scer\GAL4^unspecified leads to the formation of synaptonemal complexes in more than four cells per cyst in region 2a of the germarium and a delay in meiotic restriction in region 2b of the germarium.

(Mirouse et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

polo^UASp.cMa/Scer\GAL4^da.G32 is a suppressor | partially of abnormal mitotic cell cycle | third instar larval stage phenotype of Sgt1^c01268

(Martins et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

polo^UASp.cMa/Scer\GAL4^da.G32 is a suppressor | partially of centrosome phenotype of Sgt1^c01268

(Martins et al., 2009)

polo^UASp.cMa/Scer\GAL4^da.G32 is a suppressor | partially of spindle phenotype of Sgt1^c01268

(Martins et al., 2009)

polo^UASp.cMa/Scer\GAL4^da.G32 is a suppressor | partially of neuroblast phenotype of Sgt1^c01268

(Martins et al., 2009)

Scer\GAL4^unspecified/polo^UASp.cMa is a suppressor of oocyte phenotype of BicD^r

(Mirouse et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of polo^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^da.G32 significantly rescues the mutant phenotypes of Sgt1^c01268 larval brain neuroblasts; there is an increase in cells with a normal number of centrosomes and a normal bipolar spindle and the cells show mostly normal mitotic progression.

(Martins et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

polo^{Scer\UAS.P\T.cMa}

polo^UASp.cMa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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