FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RecQ5UAS.cNa
Open Close
General Information
Symbol
Dmel\RecQ5UAS.cNa
Species
D. melanogaster
Name
FlyBase ID
FBal0197470
Feature type
allele
Associated gene
Dmel\RecQ5
Associated Insertion(s)
Carried in Construct
P{UAS-RecQ5.N}
Key Links
Transgenic product class
cDNA
(Nakayama et al., 2006)
wild_type
(Nakayama et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Nakayama et al., 2006)
wild_type
(Nakayama et al., 2006)
Mutagen
in vitro construct
(Nakayama et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-RecQ5.N}
Cytology
Description

UASt regulatory sequences drive expression of a HpaI-SceI RecQ5 cDNA fragment.

(Nakayama et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
RecQ5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of RecQ5Scer\UAS.cNa in the eye, under the control of Scer\GAL4GMR.PF, results in mild roughening of the normally smooth ommatidial lattice. The number of ommatidia in the compound eye is similar to that in wild-type. However, the ommatidia exhibit disarray along with mislocation of interommatidial bristles.

      Expression of RecQ5Scer\UAS.cNa in the eye, under the control of Scer\GAL4GMR.PF interferes with the normal mitotic pattern in the second mitotic wave. Methyl-methanesulfonate (MMS - a DNA-damaging agent) treatment of these flies enhances the perturbation of the cell-cycle progression.

      Treatment of RecQ5Scer\UAS.cNa/Scer\GAL4GMR.PF with methyl-methanesulfonate (MMS - a DNA-damaging agent) or cisplatin magnifies the rough eye phenotype, whereas wild-type flies are not affected. Exposure does not affect viability.

      (Nakayama et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mei-41RT2 mutant enhances the rough eye phenotype of RecQ5Scer\UAS.cNa/Scer\GAL4GMR.PF flies.

      (Nakayama et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RecQ5Scer\UAS.cNa
      RecQ5UAS.cNa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)