Nakayama, M., Maruyama, S., Kanda, H., Ohkita, N., Nakano, K., Ito, F., Kawasaki, K. (2006). Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage. FEBS Lett. 580(30): 6938--6942.
FlyBase ID
FBrf0191824
Publication Type
Research paper
Abstract
Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.
