FlyBase Allele Report: Dmel\foxo[UAS.GFP]

General Information

Symbol

Dmel\foxo^UAS.GFP

Species

D. melanogaster

Name

FlyBase ID

FBal0197831

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{UAS-foxo.GFP}

Also Known As

FOXO-GFP

Key Links

Transgenic product class

wild_type

(Teleman et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Teleman et al., 2005)

Mutagen

in vitro construct

(Teleman et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-foxo.GFP}

Cytology

Description

Expression of foxo fused at the C-terminal to GFP is under the control of UASt sequences.

(Teleman et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

foxo

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Hietakangas and Cohen, 2007)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Hietakangas and Cohen, 2007)

Detailed Description

Statement

Reference

Expression of foxo^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PF results in a severely reduced eye at 25^oC, although at 18^oC the eyes are nearly normal.

(Hietakangas and Cohen, 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, foxo^UAS.GFP has visible phenotype, enhanceable by rictor^Δ2

(Hietakangas and Cohen, 2007)

Suppressor of

Statement

Reference

foxo^UAS.GFP, Scer\GAL4^NP2610-3-1 is a suppressor | partially of lethal - all die before end of pupal stage phenotype of Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

foxo^UAS.GFP, Scer\GAL4^NP2610-3-1 is a suppressor of increased cell death phenotype of Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, foxo^UAS.GFP has eye phenotype, enhanceable by rictor^Δ2

(Hietakangas and Cohen, 2007)

Suppressor of

Statement

Reference

foxo^UAS.GFP, Scer\GAL4^NP2610-3-1 is a suppressor | partially of embryonic/larval tracheal section phenotype of Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the rough eye phenotype caused by expression of foxo^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PF is enhanced by rictor^Δ2 at both 18 and 25^oC.

(Hietakangas and Cohen, 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

foxo^{Scer\UAS.T:Avic\GFP}

foxo^UAS.GFP

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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