FB2026_02 , released June 18, 2026
Allele: Dmel\tudtux46
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General Information
Symbol
Dmel\tudtux46
Species
D. melanogaster
Name
FlyBase ID
FBal0197932
Feature type
allele
Associated gene
Dmel\tud
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Thomson and Lasko, 2004)
Progenitor genotype
P{SUPor-P}KG03894
(Thomson and Lasko, 2004)
Cytology
Description

Imprecise excision of the tud insertion, resulting in a 1075bp deletion that encompasses the first exon and first intron of tud and extends into the second exon beyond the translational start site.

(Thomson and Lasko, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:21,183,242..21,184,316 [+]
Comment:

1075 bp deletion resulting from the imprecise excision of P{SUPor-P}KG03894. The sequence CATGATG remains at the site of the excision.

Inserted_sequence:

CATGATG

(Thomson and Lasko, 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mild abdominal patterning defects are seen in 4% of heterozygous embryos.

      (Jain and Gavis, 2008)

      Homozygotes grow to adulthood and are morphologically normal.

      Homozygous males have normal fertility.

      Homozygous females show no defects in oogenesis and produce eggs at levels slightly below that of wild type.

      Eggs produced by homozygous females are fertilised and 15% of the resulting embryos hatch into morphologically normal larvae. These larvae complete development, forming sterile adults whose gonads are agametic. The remaining 85% of embryos derived from homozygous females fail to hatch and have fusions and/or deletions of posterior segments.

      Embryos derived from homozygous females never contain any pole cells. Embryos derived from homozygous or tudtux46/Df(2R)PF1 females show a severe reduction in the number of polar granules (average number per embryo is 2.6 +/- 0.8 and 2.3 +/- 1.2 respectively) compared to controls (average number per embryo is 14.7 +/- 1.2). The polar granule-like structures that are present in these embryos are always much smaller and considerably less electron dense than those of controls.

      (Thomson and Lasko, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      tudtux46 has embryonic abdominal segment phenotype, enhanceable by rump[+]/rump1

      (Jain and Gavis, 2008)

      tudtux46 has embryonic abdominal segment phenotype, enhanceable by rump1/rump1

      (Jain and Gavis, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rump1 enhances in a dose-dependent manner the abdominal segmentation defects seen in tudtux46/+ embryos, with 44% of embryos showing segmental deletions and fusions in the absence of rump+. The 4th and 5th abdominal segments are most often affected.

      (Jain and Gavis, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tudtux46
      (Wang et al., 2015, Jain and Gavis, 2008, Thomson and Lasko, 2004)
      tudtux
      (Moore et al., 2009)
      tudortux46
      (Hurd et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)