FlyBase Allele Report: Dmel\rump[1]

General Information

Symbol

Dmel\rump¹

Species

D. melanogaster

Name

FlyBase ID

FBal0218192

Feature type

allele

Associated gene

Dmel\rump

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Jain and Gavis, 2008)

Progenitor genotype

rump^KG02834

(Jain and Gavis, 2008)

Cytology

Description

Imprecise excision of the insertion in rump^KG02834, resulting in a deletion starting 426bp upstream and extending 501bp downstream of the original insertion site. This deletion removes the transcription start site, the entire 5'UTR and the first 152 codons of rump.

(Jain and Gavis, 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

embryonic/larval segmentation phenotype | maternal effect

(Sinsimer et al., 2011)

lethal - all die during embryonic stage | maternal effect

(Jain and Gavis, 2008)

male semi-sterile

(Jain and Gavis, 2008)

some die during embryonic stage | maternal effect

(Jain and Gavis, 2008)

viable

(Jain and Gavis, 2008)

Phenotype Manifest In

abdominal segment

(Becalska et al., 2011)

embryonic abdominal segment

(Jain and Gavis, 2008)

larval abdominal segment | maternal effect

(Sinsimer et al., 2011)

Detailed Description

Statement

Reference

10% of rump¹ mutant embryos have less than 8 abdominal segments.

(Becalska et al., 2011)

Of embryos from rump¹ mothers that complete embryogenesis, 11% show abdominal segmentation defects.

(Sinsimer et al., 2011)

Homozygous females show a variable maternal-effect defect in the percentage of progeny that complete embryonic development, ranging from 29% to 65%.

Homozygous males derived from heterozygous parents show reduced fertility; only 10% of males are able to fertilise virgin females within a 10 day period.

Embryos derived from homozygous females show a weak, though significant, segmentation defect, which is variable in its penetrance.

(Jain and Gavis, 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

rump¹ is an enhancer of embryonic/larval segmentation phenotype | maternal effect phenotype of lost¹

(Sinsimer et al., 2011)

Other

Statement

Reference

lost¹, rump¹ has partially lethal - majority die | maternal effect | embryonic stage phenotype

(Sinsimer et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

rump¹ has abdominal segment phenotype, enhanceable by aub[+]/aub^QC42

(Becalska et al., 2011)

rump¹ has abdominal segment phenotype, enhanceable by nanos^BN/nanos^+1+3.Tag:MS2

(Becalska et al., 2011)

aub[+]/aub^QC42, rump¹ has abdominal segment phenotype, enhanceable by nanos^BN/nanos^+1+3.Tag:MS2

(Becalska et al., 2011)

rump¹ has embryonic abdominal segment phenotype, enhanceable by nanos^BN/nos[+]

(Jain and Gavis, 2008)

Enhancer of

Statement

Reference

rump¹ is an enhancer of larval abdominal segment | maternal effect phenotype of lost¹

(Sinsimer et al., 2011)

rump[+]/rump¹ is an enhancer of embryonic abdominal segment phenotype of tud^tux46

(Jain and Gavis, 2008)

rump¹/rump¹ is an enhancer of embryonic abdominal segment phenotype of tud^tux46

(Jain and Gavis, 2008)

Other

Statement

Reference

lost¹, rump¹ has primordial germ cell | maternal effect phenotype

(Sinsimer et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

rump¹ mutant embryos carrying a aub^QC42/+ mutation display an increase in the number of embryos that develop less than 8 abdominal segments.

rump¹ mutant embryos carrying a nos^BN, nos^{+1+3.T:MS2\MCP.BS}/nos^BN mutation display an increase in the number of embryos that develop less than 8 abdominal segments.

rump¹ mutant embryos carrying an aub^QC42/+ mutation, and the mutation nos^BN, nos^{+1+3.T:MS2\MCP.BS}/nos^BN , display an increase in the number of embryos that develop less than 8 abdominal segments.

(Becalska et al., 2011)

54% of embryos from lost¹, rump¹ mothers fail to develop.

Abdominal segmentation defects are more prevalent among surviving lost¹, rump¹ progeny (18%) than for either lost¹ (7%) or rump¹ (11%).

Embryos from lost¹, rump¹ mothers have significantly fewer pole cells than wild type.

(Sinsimer et al., 2011)

The frequency and severity of abdominal segmentation defects in embryos derived from rump¹ homozygous females is increased by one copy of nos^BN. Abdominal segments 4 and 5 are most frequently affected.

rump¹ enhances in a dose-dependent manner the abdominal segmentation defects seen in tud^tux46/+ embryos, with 44% of embryos showing segmental deletions and fusions in the absence of rump⁺. The 4th and 5th abdominal segments are most often affected.

The ability of nos^nos.+2.Hsp83 to rescue abdominal segmentation of nos^BN embryos is severely compromised in a rump¹/Df(3R)by416 background; more than 90% of the embryos develop fewer than 4 abdominal segments.

(Jain and Gavis, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

rump¹ is rescued by rump^+t6.5

(Jain and Gavis, 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

57697

st^* rump¹ e¹

57696

ry⁵⁰⁶ rump¹/TM3, P{hs-hid}14, ry^* Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

r¹

(Sinsimer et al., 2011)

rump¹

(Titus et al., 2023, King et al., 2014, Becalska et al., 2011, Sinsimer et al., 2011, Jain and Gavis, 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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