FlyBase Allele Report: Dmel\lost[1]

General Information

Symbol

Dmel\lost¹

Species

D. melanogaster

Name

FlyBase ID

FBal0263648

Feature type

allele

Associated gene

Dmel\lost

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Sinsimer et al., 2011)

Mutagen

P-element activity

(Sinsimer et al., 2011)

Progenitor genotype

P{PTT-GA}lost^ZCL3169

(Sinsimer et al., 2011)

Caused by aberration

Df(3R)lost¹

Cytology

Description

Imprecise excision of P{PTT-GA}lost^ZCL3169, creating a ~4 kb deletion that removes both predicted transcriptional start sites of lost and the first exon containing the translation start site of lost.

(Sinsimer et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

embryonic/larval segmentation phenotype | maternal effect

(Sinsimer et al., 2011)

female fertile

(Sinsimer et al., 2011)

male sterile | recessive

(Sinsimer et al., 2011)

partially lethal - majority die | maternal effect

(Sinsimer et al., 2011)

some die during embryonic stage | maternal effect

(Sinsimer et al., 2011)

Phenotype Manifest In

larval abdominal segment | maternal effect

(Sinsimer et al., 2011)

Detailed Description

Statement

Reference

59% of embryos produced from lost¹ females fail to develop. Of those that complete embryogenesis, 7% show mild abdominal segmentation defects (partial deletions or fusions of segments).

(Sinsimer et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lost¹ has embryonic/larval segmentation phenotype | maternal effect phenotype, enhanceable by rump¹

(Sinsimer et al., 2011)

Other

Statement

Reference

lost¹, rump¹ has partially lethal - majority die | maternal effect | embryonic stage phenotype

(Sinsimer et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

lost¹ has larval abdominal segment | maternal effect phenotype, enhanceable by rump¹

(Sinsimer et al., 2011)

Other

Statement

Reference

lost¹, rump¹ has primordial germ cell | maternal effect phenotype

(Sinsimer et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

54% of embryos from lost¹, rump¹ mothers fail to develop.

Abdominal segmentation defects are more prevalent among surviving lost¹, rump¹ progeny (18%) than for either lost¹ (7%) or rump¹ (11%).

Embryos from lost¹, rump¹ mothers have significantly fewer pole cells than wild type.

(Sinsimer et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

lost¹ is rescued by lost^+t5.7

(Sinsimer et al., 2011)

Comments

All lost¹ phenotypes are rescued by a single copy of lost^+t5.7.

(Sinsimer et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57695

Df(3R)lost¹, lost¹ ry⁵⁰⁶/TM3, ry^* Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

l¹

(Sinsimer et al., 2011)

lost¹

(Fingerhut et al., 2019, Sinsimer et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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