FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MTF-1unspecified
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General Information
Symbol
Dmel\MTF-1unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0197963
Feature type
allele
Associated gene
Dmel\MTF-1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Alzheimer's disease
        modeled by Hsap\APPAβ42.UAS.Tag:SS(hh)
        (Hua et al., 2011)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants are highly sensitive to copper and cadmium load in food, showing dramatically reduced survival on 0.5mM copper or 50μM cadmium concentrations. The mutants are also sensitive to copper depletion. Mutants also show reduced survival on 4mM zinc, 50μM silver and 250μM mercury concentrations compared to controls.

        (Egli et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        MTF-1unspecified is an enhancer of eye phenotype of Hsap\APPAβ42.UAS.Tag:SS(hh), Scer\GAL4GMR.PF

        (Hua et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        MTF-1unspecified enhances the eye phenotype caused by sxpression of Hsap\APPAβ42.Scer\UAS.T:hh under the control of Scer\GAL4GMR.PF.

        (Hua et al., 2011)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        MTF-1-
        (Hua et al., 2011)
        MTF-1unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (5)