FlyBase Allele Report: Dmel\Abl[GD1344]

General Information

Symbol

Dmel\Abl^GD1344

Species

D. melanogaster

Name

FlyBase ID

FBal0198637

Feature type

allele

Associated gene

Dmel\Abl

Associated Insertion(s)

Carried in Construct

P{GD1344}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1344}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1344

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Detailed Description

Statement

Reference

Expressing Abl^GD1344 under the control of Scer\GAL4^GMR.PU induces a very mild rough eye phenotype.

Expressing Abl^GD1344 under the control of Scer\GAL4^dome.PU does not induce melanotic masses in third instar larvae.

(Bernardoni et al., 2019)

Adults expressing Abl^GD1344 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing Abl^GD1344 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Scer\GAL4^GMR.PU-driven expression of a weak Abl^GD1344 transgene has no axon targeting phenotype in larval eye/brain complexes.

(Xiong et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1344

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Abl^GD1344, Scer\GAL4^GMR.PU is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^GD1441

(Xiong et al., 2009)

NOT Enhancer of

Statement

Reference

Scer\GAL80^ts.αTub84B, Abl^GD1344, Scer\GAL4^da.PU is a non-enhancer of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

Suppressor of

Statement

Reference

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^GD1344, Scer\GAL4^dome.PU is a suppressor | partially of melanotic mass phenotype | third instar larval stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^dome.PU

(Bernardoni et al., 2019)

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^WT.UAS

(Xiong et al., 2009)

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^{WT.UAS.Tag:Myr(v-Src)}

(Xiong et al., 2009)

NOT Suppressor of

Statement

Reference

Scer\GAL80^ts.αTub84B, Abl^GD1344, Scer\GAL4^da.PU is a non-suppressor of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Abl^GD1344, Scer\GAL4^GMR.PU is an enhancer of larval brain | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^GD1441

(Xiong et al., 2009)

Suppressor of

Statement

Reference

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of larval brain | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^WT.UAS

(Xiong et al., 2009)

Abl^GD1344, Scer\GAL4^GMR.PU is a suppressor of larval brain | third instar larval stage phenotype of Scer\GAL4^GMR.PU, eya^{WT.UAS.Tag:Myr(v-Src)}

(Xiong et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of Abl^GD1344 increases the number of axon targeting defects in Scer\GAL4^GMR.PU eya^GD1441 eye/brain complexes from 18.2 to 21.8 axon bundles per brain.

Coexpression of Abl^GD1344 decreases the number of axon targeting defects in Scer\GAL4^GMR.PU eya^WT.Scer\UAS eye/brain complexes from 25.7 to 12.4 axon bundles per brain.

Coexpression of Abl^GD1344 decreases the number of axon targeting defects in Scer\GAL4^GMR.PU eya^{WT.Scer\UAS.T:Uuuu\Myr4} eye/brain complexes from 19.0 to 8.7 axon bundles per brain.

(Xiong et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v2897

w¹¹¹⁸ P{GD1344}v2897

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1344

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Abl^GD1344

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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