FlyBase Allele Report: Dmel\Akap200[GD1207]

General Information

Symbol

Dmel\Akap200^GD1207

Species

D. melanogaster

Name

FlyBase ID

FBal0198696

Feature type

allele

Associated gene

Dmel\Akap200

Associated Insertion(s)

Carried in Construct

P{GD1207}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1207}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1207

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Parkhurst et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^en-e16E

(Weber et al., 2012)

Phenotype Manifest In

wing vein, with Scer\GAL4^en-e16E

(Weber et al., 2012)

Detailed Description

Statement

Reference

Expression of Akap200^GD1207 under the control of Scer\GAL4^en-e16E results in wing vein defects.

Flies expressing CG10068^GD6063 under the control of either one of Scer\GAL4^dpp.blk1 or Scer\GAL4^ap-md544 display normal planar cell polarity in the eye and the wing.

(Weber et al., 2012)

Adults expressing Akap200^GD1207 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) can show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies, depending on the particular P{GD1207} insertion line used.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1207

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Akap200^GD1207, Scer\GAL4^hs.2sev is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Akap200^GD1207, Scer\GAL4^hs.2sev is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

Akap200^GD1207, Dcr-2^UAS.cDa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype

(Weber et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Akap200^GD1207, Scer\GAL4^hs.2sev is a suppressor | partially of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Akap200^GD1207, Scer\GAL4^hs.2sev is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

Akap200^GD1207, Dcr-2^UAS.cDa, Scer\GAL4^hs.2sev has ommatidium phenotype

(Weber et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Akap200^GD1207 and Dcr-2^Scer\UAS.cDa using Scer\GAL4^hs.2sev results in planar cell polarity (PCP)-abnormalities and loss of ommatidia.

(Weber et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1207

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Akap200^GD1207

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close