FlyBase Allele Report: Dmel\Atpα[GD3093]

General Information

Symbol

Dmel\Atpα^GD3093

Species

D. melanogaster

Name

FlyBase ID

FBal0198792

Feature type

allele

Associated gene

Dmel\Atpα

Associated Insertion(s)

Carried in Construct

P{GD3093}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD3093}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD3093

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Johnston organ, with Scer\GAL4^nompA.cK

(Roy et al., 2013)

Detailed Description

Statement

Reference

Flies expressing Atpα^GD3093 under the control of either Scer\GAL4^ato.PU or Scer\GAL4^nompA.cK are deaf, with complete loss of sound-evoked potentials in the antennal nerve.

Adults expressing Atpα^GD3093 under the control of Scer\GAL4^nompA.cK show abnormal accumulation of electron-dense material in the Johnston's organ scolopale space. This material includes membrane-bound organelles such as mitochondria.

(Roy et al., 2013)

Adults expressing Atpα^GD3093 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development