FlyBase Allele Report: Dmel\CG17019[GD1336]

General Information

Symbol

Dmel\CG17019^GD1336

Species

D. melanogaster

Name

FlyBase ID

FBal0201714

Feature type

allele

Associated gene

Dmel\CG17019

Associated Insertion(s)

Carried in Construct

P{GD1336}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1336}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1336

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^how-24B

(Wei et al., 2018)

abnormal stress response | adult stage, with Scer\GAL4^how-24B

(Wei et al., 2018)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

indirect flight muscle cell, with Scer\GAL4^how-24B

(Wei et al., 2018)

mitochondrion | adult stage, with Scer\GAL4^how-24B

(Wei et al., 2018)

Detailed Description

Statement

Reference

Expressing CG17019^GD1336 under the control of Scer\GAL4^how-24B results in a significantly increased mitochondrial density in indirect flight muscles and faster climbing speeds in middle-aged adults at day 20 (but not in younger or older flies) compared to wild-type controls. When exposed to constant flipping in a Power Tower Machine, adult flies display a significantly longer time to climbing exhaustion than wild-type controls.

Expressing CG17019^GD1336 under the control of Scer\GAL4^how-24B has no effect on body weight or food intake in adult flies.

(Wei et al., 2018)

Adults expressing CG17019^GD1336 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development