FlyBase Allele Report: Dmel\CG17760[GD17286]

General Information

Symbol

Dmel\CG17760^GD17286

Species

D. melanogaster

Name

FlyBase ID

FBal0201946

Feature type

allele

Associated gene

Dmel\CG17760

Associated Insertion(s)

Carried in Construct

P{GD17286}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD17286}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD17286

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | early third instar larval stage | conditional, with Scer\GAL4^ppk.1.9

(Im et al., 2015)

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

24 hours after UV-induced nociceptive sensitization, larvae with expression of CG17760^GD17286 driven by Scer\GAL4^ppk.1.9 show significant reduction of thermal allodynia (withdrawal responses to a sub-threshold 38[o]C probe) compared to controls.

(Im et al., 2015)

Expression of CG17760^GD17286 driven by Scer\GAL4^phm.PO does not lead to developmental delay/arrest at the larval stage.

(Yamanaka et al., 2015)

Adults expressing CG17760^GD17286 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CG17760^GD17286, Scer\GAL4^ppk.1.9 is a suppressor | partially of abnormal pain response | early third instar larval stage | heat sensitive phenotype of Scer\GAL4^ppk.1.9, TkR99D^UAS.EGFP

(Im et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of CG17760^GD17286 significantly partially suppresses the withdrawal responses to a 38[o]C probe (without pre-exposure to UV) seen in early third instar larvae with TkR99D^{Scer\UAS.T:Avic\GFP-EGFP} over-expressed by Scer\GAL4^ppk.1.9.

(Im et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v52308

w¹¹¹⁸; P{GD17286}v52308

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG17760^GD17286

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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