Expression of meep^GD10860 under the control of Scer\GAL4^r4 leads to a reduction in larval survival when animals are reared on normal food (partially lethal), food containing 0.7 M (HSD- partially lethal) or 1 M (lethal) sucrose. Its expression also leads to a decrease in third instar larval body weight when animals are reared on a HSD; a delay in development and a reduction in pupariation success when animals are reared on normal diet or a HSD; short lived females and males that are fed with HSD however long lived females under normal conditions.

Adults expressing CG32335^GD10860 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 0% or 60-70% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.