FlyBase Allele Report: Dmel\Indy[GD2712]

General Information

Symbol

Dmel\Indy^GD2712

Species

D. melanogaster

Name

FlyBase ID

FBal0207384

Feature type

allele

Associated gene

Dmel\Indy

Associated Insertion(s)

Carried in Construct

P{GD2712}

Also Known As

UAS-Indy^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2712}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2712

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Kohlschutter-Tonz syndrome

CEA

(Jeong et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Kohlschutter-Tonz syndrome

is ameliorated by VGlut1^UAS.cDa

(Jeong et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Indy^GD2712 under the control of Scer\GAL4^GMR.long does not induce any obvious eye phenotype, as compared to controls.

(Yan et al., 2019)

Expressing Indy^GD2712 under the control of Scer\GAL4^fkh.PH does not significantly affect the clearing of salivary gland tissue in pupae, as compared to controls.

(Velentzas et al., 2018)

Adults expressing Indy^GD2712 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development