FlyBase Allele Report: Dmel\Ptp10D[GD2611]

General Information

Symbol

Dmel\Ptp10D^GD2611

Species

D. melanogaster

Name

FlyBase ID

FBal0208158

Feature type

allele

Associated gene

Dmel\Ptp10D

Associated Insertion(s)

Carried in Construct

P{GD2611}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2611}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2611

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

The expression of Ptp10D^GD2611 under the control of Scer\GAL4^ppk.PG, in combination with Dicer-2 for efficient RNAi, results in a reduced dendritic arborization in third instar larval class IV abdominal dorsal multidendritic ddaC neurons, as compared to controls; expression under the control of Scer\GAL4²²¹, in combination with Dicer-2 for efficient RNAi, results in no obvious dendrite morphology defects in class I abdominal dorsal multidendritic ddaD and ddaE neurons, as compared to controls.

(Hattori et al., 2013)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 60-70% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 30-40% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 20-30% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2611

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ptp10D^GD2611, Scer\GAL4^ninaE.PT is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ptp10D^GD2611, Scer\GAL4^ninaE.PT is an enhancer of retina | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Ptp10D^GD2611, Scer\GAL4^ninaE.PT is an enhancer of ommatidium | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-progressive retinal degeneration characteristic for flies expressing Hsap\SNCA^Scer\UAS.cJa under the control of Scer\GAL4^ninaE.PT is significantly enhanced by co-expression of Ptp10D^GD2611.

(Jansen et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v8010

w¹¹¹⁸; P{GD2611}v8010

Notes on Origin

Discoverer