FlyBase Allele Report: Dmel\Zip42C.1[GD1830]

General Information

Symbol

Dmel\Zip42C.1^GD1830

Species

D. melanogaster

Name

FlyBase ID

FBal0209022

Feature type

allele

Associated gene

Dmel\Zip42C.1

Associated Insertion(s)

Carried in Construct

P{GD1830}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1830}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1830

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lang et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during larval stage, with Scer\GAL4^Tub.PU

(Lye et al., 2012)

melanotic mass phenotype, with Scer\GAL4^Tub.PU

(Lye et al., 2012)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

melanotic mass, with Scer\GAL4^Tub.PU

(Lye et al., 2012)

Detailed Description

Statement

Reference

Expression of Zip42C.1^GD1830 under the control of Scer\GAL4^tub.PU results in early larval lethality and melanotic masses.

Expression of Zip42C.1^GD1830 under the control of Scer\GAL4^GMR.PFa does not result in a mutant phenotype.

Expression of Zip42C.1^GD1830 under the control of Scer\GAL4^pnr-MD237 does not result in a mutant phenotype.

(Lye et al., 2012)

Adults expressing Zip42C.1^GD1830 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1830

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Zip42C.1^GD1830, Scer\GAL4^elav.PLu is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PLu

(Lang et al., 2012)

Zip42C.1^GD1830, Scer\GAL4^elav.PLu is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PLu

(Lang et al., 2012)

NOT Suppressor of

Statement

Reference

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Zip42C.1^GD1830, Scer\GAL4^elav.PLu is a suppressor of adult brain phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PLu

(Lang et al., 2012)

NOT Suppressor of

Statement

Reference

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.1^GD1830/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long do not change upon co-expression of Zip42C.1^GD1830 RNAi.

The morphological and pigmentation defects in the adult eye seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long do not change upon co-expression of Zip42C.1^GD1830 RNAi.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Expression of ZIP1^GD1830 suppresses the brain vacuolisation phenotype seen in 20 day old flies when Hsap\APP^{Aβ1-42.Scer\UAS.cIa} is expressed under the control of Scer\GAL4^elav.PLu.

Expression of ZIP1^GD1830 suppresses the locomotor defects seen when Hsap\APP^{Aβ1-42.Scer\UAS.cIa} is expressed under the control of Scer\GAL4^elav.PLu. Flies begin to display climbing defects at around 30 days after eclosion, rather than 20-25 days as is seen when Hsap\APP^{Aβ1-42.Scer\UAS.cIa} is expressed alone.

(Lang et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v3987

w¹¹¹⁸; P{GD1830}v3987

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1830

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ZIP1^GD1830

Zip42C.1^GD1830

dZip42C.1^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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