FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dveGD1425
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General Information
Symbol
Dmel\dveGD1425
Species
D. melanogaster
Name
FlyBase ID
FBal0209447
Feature type
allele
Associated gene
Dmel\dve
Associated Insertion(s)
Carried in Construct
P{GD1425}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1425}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1425
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dveGD1425 in the midgut at 25[o]C under the control of Scer\GAL4NP3123 results in the copper cells exhibiting abnormal morphology in male progeny. Both sexes exhibit a reduction in midgut function, including acid secretion and copper absorption.

      Expression of dveGD1425 in the midgut at 25[o]C under the control of Scer\GAL4NP3012 has no effect on acid secretion in the midgut but reduces copper absorption.

      Expression of dveGD1425 in copper cells at 25[o]C under the control of Scer\GAL4NP3270 has little effect on copper absorption but reduces acid secretion in the midgut.

      Expression of dveGD1425 in copper cells at 25[o]C under the control of Scer\GAL4NP3157 has little effect on copper absorption but reduces acid secretion in the midgut.

      Expression of dveGD1425 in interstitial cells at 25[o]C under the control of Scer\GAL4NP3207 or Scer\GAL4NP3612 has a mild effect on copper absorption and acid secretion in the midgut.

      (Nakagawa et al., 2011)

      Expression under the control of Scer\GAL4pnr-MD237 may result in lethality before the pupal stage, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dveGD1425
      Name Synonyms
      Secondary FlyBase IDs
        References (5)