FlyBase Allele Report: Dmel\fwd[GD12100]

General Information

Symbol

Dmel\fwd^GD12100

Species

D. melanogaster

Name

FlyBase ID

FBal0209610

Feature type

allele

Associated gene

Dmel\fwd

Associated Insertion(s)

Carried in Construct

P{GD12100}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD12100}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD12100

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing blade, with Scer\GAL4^en-e16E

(Weber et al., 2012)

wing hair | increased number, with Scer\GAL4^ap-md544

(Weber et al., 2012)

Detailed Description

Statement

Reference

Escapers expressing fwd^GD12100 under the control of Scer\GAL4^en-e16E display wing notches.

Expression of fwd^GD12100 under the control of Scer\GAL4^ap-md544 results in multiple cellular hairs in the wing.

(Weber et al., 2012)

Adults expressing fwd^GD12100 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in viable flies or late larval lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in lethality, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

12100

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

fwd^GD12100/Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

fwd^GD12100/Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^hs.2sev, fwd^GD12100 has abnormal planar polarity phenotype

(Weber et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

fwd^GD12100/Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

fwd^GD12100/Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

Scer\GAL4^drm.7.1, fwd^GD12100, trc^GL01127 has embryonic/larval dorsal tracheal branch | larval stage phenotype

(Hudson et al., 2023)

Dcr-2^UAS.cDa, Scer\GAL4^hs.2sev, fwd^GD12100 has ommatidium phenotype

(Weber et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of fwd^GD12100 with Dcr-2^Scer\UAS.cDa using Scer\GAL4^hs.2sev results in ommatidial planar cell polarity (PCP)-defects in the eye.

(Weber et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v27786

w¹¹¹⁸; P{GD12100}v27786

v27785

w¹¹¹⁸; P{GD12100}v27785/TM3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

12100

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fwd^GD12100

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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