FlyBase Allele Report: Dmel\niki[GD7142]

General Information

Symbol

Dmel\niki^GD7142

Species

D. melanogaster

Name

FlyBase ID

FBal0210194

Feature type

allele

Associated gene

Dmel\niki

Associated Insertion(s)

Carried in Construct

P{GD7142}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7142}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7142

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis type 24

CEA

(Mann et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis type 24

is ameliorated by Hsap\TUBA1B^UAS.mCherry

(Mann et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

short lived, with Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

larval brain | larval stage, with Scer\GAL4^Toll-6-D42

(Mann et al., 2023)

Detailed Description

Statement

Reference

Adults expressing niki^GD7142 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7142

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^VGlut1-OK371, niki^GD7142 has decreased rate of adult locomotory behavior | progressive phenotype, non-enhanceable by Fs(2)Ket^KK100714, Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^VGlut1-OK371, niki^GD7142 has decreased rate of adult locomotory behavior | progressive phenotype, suppressible | partially by Hsap\TUBA1B^UAS.mCherry, Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

NOT suppressed by

Statement

Reference

Scer\GAL4^VGlut1-OK371, niki^GD7142 has decreased rate of adult locomotory behavior | progressive phenotype, non-suppressible by Fs(2)Ket^KK100714, Scer\GAL4^VGlut1-OK371

(Mann et al., 2023)

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.PU/niki^GD7142, Scer\GAL80^ts.αTub84B is a non-enhancer of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/niki^GD7142, Scer\GAL80^ts.αTub84B is a non-suppressor of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v16120

w¹¹¹⁸; P{GD7142}v16120

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7142

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

niki^GD7142

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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