FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CtsL1CC01377
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General Information
Symbol
Dmel\CtsL1CC01377
Species
D. melanogaster
Name
FlyBase ID
FBal0211669
Feature type
allele
Associated gene
Dmel\CtsL1
Associated Insertion(s)
P{PTT-GC}CtsL1CC01377
Carried in Construct
Also Known As
CC01377, CP1-GFP
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Buszczak et al., 2007)
Progenitor genotype
Associated Insertion(s)
P{PTT-GC}CtsL1CC01377
Cytology
Description

Insertion within an intron located between two coding exons, in the appropriate predicted reading frame to fuse the GFP exon in the inserted construct to the endogenous protein.

(Buszczak et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{PTT-GC}
Tagged with
EGFP
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of germline cells per egg chamber is reduced compared to wild type in Cp1CC01377 females in which the "tag-mediated loss of function" method has been used to knock down expression of the Cp1 gene (the females express either Avic\GFPdsRNA.shRNA.Scer\UAS.P\T.1 or Avic\GFPdsRNA.shRNA.Scer\UAS.P\T.2 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 which produce shRNA that targets the Avic\GFP-tagged Cp1CC01377 transcript). Apoptosis is not triggered in the germline in these females. A high frequency of apoptosis is seen in these females, mostly in cystocytes in region 2 of the germarium, but also at later stages of oogenesis.

      (Neumüller et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      CtsL1CC01377/Cp1[+] is a suppressor | partially of visible | adult stage phenotype of MitfUAS.cZa, Scer\GAL4dpp.blk1

      (Zhang et al., 2015)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      CtsL1CC01377/Cp1[+] is a suppressor | partially of wing | adult stage phenotype of MitfUAS.cZa, Scer\GAL4dpp.blk1

      (Zhang et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small underdeveloped wing characteristic for adult flies expressing MitfScer\UAS.cZa under the control of Scer\GAL4dpp.blk1 is significantly suppressed by combination with a single copy of Cp1CC01377.

      (Zhang et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein trap line.

      (Buszczak et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cp1CC01377
      CtsL1CC01377
      Name Synonyms
      Secondary FlyBase IDs
        References (3)