FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ccs29E
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General Information
Symbol
Dmel\Ccs29E
Species
D. melanogaster
Name
FlyBase ID
FBal0212656
Feature type
allele
Associated gene
Dmel\Ccs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kirby et al., 2008)

loss of function allele

(Phillips, 2007.12.21)
Mutagen
P-element activity
(Phillips, 2007.12.21)
Progenitor genotype
Cytology
Description

1907bp deletion extending upstream from nucleotide 124 of the second exon through the first intron, the first exon and 1717bp of 5' non-coding region.

(Kirby et al., 2008)

Imprecise excision of a P-element insertion.

(Phillips, 2007.12.21)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:10,122,335..10,124,241 [-]
Comment:

A 1907 bp deletion resulting from the apparent imprecise excision of a P element insertion. The position of the deletion on the reference sequence was inferred by a FlyBase curator.

(Kirby et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous flies show an approximately 30% reduction in median adult lifespan compared to controls and are extremely hypersensitive to paraquat.

      (Kirby et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Ccs29E has short lived phenotype, suppressible by Hsap\SOD1UAS.cPa/Scer\GAL4da.G32

      (Kirby et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\SOD1Scer\UAS.cPa under the control of Scer\GAL4da.G32 rescues the early mortality and reduced median lifespan of Ccs29E homozygotes.

      (Kirby et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CCS29E
      (Phillips, 2007.12.21)
      Ccs29E
      Ccsn29E
      (Kirby et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)