FlyBase Allele Report: Dmel\Imp[7]

General Information

Symbol

Dmel\Imp⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0212706

Feature type

allele

Associated gene

Dmel\Imp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Munro et al., 2006)

Progenitor genotype

Imp^EP760

(Munro et al., 2006)

Cytology

Description

Excision of P{EP}Imp^EP760 removes a large portion of the Imp-coding region (from exon 8 to exon 10).

(Munro et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Vijayakumar et al., 2019, Medioni et al., 2014)

Phenotype Manifest In

gamma Kenyon cell | adult stage | somatic clone

(Vijayakumar et al., 2019, Medioni et al., 2014)

Detailed Description

Statement

Reference

Imp⁷ homozygous mutant MARCM mushroom body γ neuron clones in adults have an increased number of neurons that fail to elongate properly, compared to controls.

(Vijayakumar et al., 2019)

In contrast to wild type, about 50% of single Imp⁷ γ axons (generated via MARCM) fail to reach the end of the medial lobe in the adult. These defects do not result from axon retraction, and mutant axons of normal length but lost directionality are observed. Mutant neurons also exhibit an overall decrease in the complexity of axonal arborization patterns, characterized by a reduced number of terminal branches.

Both single larval γ neurons and single adult α'β' neurons mutant for Imp⁷ project their axons normally, and larval γ neuron neuroblast clones exhibit a normal morphology - the Imp⁷ neuronal phenotype is restricted to adult γ axons.

(Medioni et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Imp⁷ has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Tab2-201Y/chic^UAS.cCa

(Medioni et al., 2014)

Imp⁷ has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Tab2-201Y/chic^UAS.Tag:MS2

(Medioni et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Imp⁷ has gamma Kenyon cell | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Tab2-201Y/chic^UAS.cCa

(Medioni et al., 2014)

Imp⁷ has gamma Kenyon cell | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Tab2-201Y/chic^UAS.Tag:MS2

(Medioni et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^Tab2-201Y-mediated expression of chic^Scer\UAS.cCa or chic^{Scer\UAS.T:MS2\MCP.BS} significantly suppresses the γ axon growth phenotype of Imp⁷ mutant neurons.

(Medioni et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Imp⁷ is partially rescued by Scer\GAL4^Tab2-201Y/Imp^UAS.GFP

(Vijayakumar et al., 2019)

Imp⁷ is partially rescued by Scer\GAL4^Tab2-201Y/Imp^{Nter-PLD.UAS.GFP}

(Vijayakumar et al., 2019)

Imp⁷ is partially rescued by Scer\GAL4^Tab2-201Y/Imp^{UASp.Tag:FLAG}

(Medioni et al., 2014)

Not rescued by

Imp⁷ is not rescued by Scer\GAL4^Tab2-201Y/Imp^{ΔPLD.UAS.GFP}

(Vijayakumar et al., 2019)

Comments

Scer\GAL4^Tab2-201Y-mediated expression of Imp^{Scer\UAS.P\T.T:Zzzz\FLAG} significantly suppresses the γ axon regrowth/branching phenotype of Imp⁷ mutants.

(Medioni et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Imp⁷

(Fisher et al., 2025, Guan et al., 2022, Syed et al., 2017, Narbonne-Reveau et al., 2016, Liu et al., 2015, Toledano et al., 2012, Munro et al., 2006)

imp⁷

(Fic et al., 2019, Vijayakumar et al., 2019, Medioni et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (10)

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