FlyBase Allele Report: Dmel\Imp[8]

General Information

Symbol

Dmel\Imp⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0212707

Feature type

allele

Associated gene

Dmel\Imp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Munro et al., 2006)

Progenitor genotype

Imp^EP760

(Munro et al., 2006)

Cytology

Description

Excision of P{EP}Imp^EP760 removes a large portion of the Imp-coding region (from the middle of intron 6 to exon 10).

(Munro et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Hattori et al., 2013)

abnormal neuroanatomy | adult stage | somatic clone

(Medioni et al., 2014)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | somatic clone | third instar larval stage

(Hattori et al., 2013)

dendritic tree | somatic clone | third instar larval stage

(Hattori et al., 2013)

gamma Kenyon cell | adult stage | somatic clone

(Medioni et al., 2014)

Detailed Description

Statement

Reference

In contrast to wild type, about 50% of Imp⁸ γ axons (generated via MARCM) fail to reach the end of the medial lobe. These defects do not result from axon retraction, and mutant axons of normal length but lost directionality are observed. Mutant neurons also exhibit an overall decrease in the complexity of axonal arborization patterns, characterized by a reduced number of terminal branches.

(Medioni et al., 2014)

Class I abdominal dorsal multidendritic ddaD and ddaE neurons of Imp⁸ hemizygous mutant third instar larvae show similar number of dendrite branch terminals, as compared to controls.

Class IV abdominal dorsal multidendritic ddaC neurons of Imp⁸ hemizygous mutant third instar larvae show significant decreases in the number and cumulative length of dendrite branch terminals, as compared to controls.

(Hattori et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Imp[+]/Imp⁸ is an enhancer of abnormal neuroanatomy phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Imp[+]/Imp⁸ is an enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A Imp⁸/+ background enhances the visual system degeneration seen in Scer\GAL4^GMR.PF, Ppt1^Scer\UAS.cKa flies.

(Saja et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Imp⁸

(van den Ameele and Brand, 2019, Hattori et al., 2013, Toledano et al., 2012, Saja et al., 2010, Munro et al., 2006)

imp⁸

(Fic et al., 2019, Medioni et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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