FB2026_02 , released June 18, 2026
Allele: Dmel\scramb1UAS.cAa
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General Information
Symbol
Dmel\scramb1UAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Acharya
FlyBase ID
FBal0212824
Feature type
allele
Associated gene
Dmel\scramb1
Associated Insertion(s)
Carried in Construct
P{UAS-scramb1.A}
Key Links
Transgenic product class
genomic_DNA
(Acharya et al., 2006)
wild_type
(Acharya et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Acharya et al., 2006)
wild_type
(Acharya et al., 2006)
Mutagen
in vitro construct
(Acharya et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-scramb1.A}
Cytology
Description

An 11.8kb fragment of genomic DNA spanning the scramb1 gene is cloned downstream of UASt regulatory sequences.

(Acharya et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
scramb1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of scramb1Scer\UAS.cAa, under the control of Scer\GAL4Act does not affect rprGMR.PW-induced photoreceptor apoptosis. The eye sizes are not significantly different in the three mutant backgrounds compared with control flies.

      (Acharya et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of scramb1Scer\UAS.cAa with scramb2Scer\UAS.cAa, under the control of Scer\GAL4Act does not affect rprGMR.PW-induced photoreceptor apoptosis. The eye sizes are not significantly different in the three mutant backgrounds compared with control flies.

      The extent of FM1-43 dye loading in scramb1Δ38/scramb2Δ57 double mutants can be rescued to control levels through the expression of scramb1Scer\UAS.cAa under the control of Scer\GAL4Act.

      Reserve pool recruitment of synaptic vesicles in scramb1Δ38/scramb2Δ57 double mutant larvae is rescued to control levels through the expression of scramb1Scer\UAS.cAa under the control of Scer\GAL4Act.

      (Acharya et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      scramb1Scer\UAS.cAa
      scramb1UAS.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Acharya
      Secondary FlyBase IDs
        References (1)