FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PLPP3UAS.EGFP
Open Close
General Information
Symbol
Hsap\PLPP3UAS.EGFP
Species
H. sapiens
Name
FlyBase ID
FBal0212958
Feature type
allele
Associated gene
Hsap\PLPP3
Associated Insertion(s)
Carried in Construct
P{UAS-hLPP3.EGFP}
Key Links
Transgenic product class
wild_type
(Burnett and Howard, 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Burnett and Howard, 2003)
Mutagen
in vitro construct
(Burnett and Howard, 2003)
Progenitor genotype
Carried in construct
P{UAS-hLPP3.EGFP}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\PLPP3 tagged at the C-terminal end with EGFP.

(Burnett and Howard, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PLPP3
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing Hsap\PPAP2BScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4twi.PG show a reduction in the number of primordial germ cells (PGCs) and defects in PGC migration.

      (Burnett and Howard, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The germ cell death seen in embryos with a wun2+ soma which are derived from wun2EP2650ex34/Df(2R)wun-GL females is rescued by expression of Hsap\PPAP2BScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

      Expression of Hsap\PPAP2BScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in the germ cells partially suppresses the reduction in germ cell number seen in embryos expressing wun2αTub84B.T:Hsap\MYC in the soma.

      (Renault et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "Human LPP3-GFP", transfected into S2 cells and used to study the catalytic activity of the protein produced.

      (Burnett and Howard, 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\PLPP3Scer\UAS.T:Avic\GFP-EGFP
      Hsap\PLPP3UAS.EGFP
      Hsap\PPAP2BScer\UAS.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)