FlyBase Allele Report: Dmel\vari[R3]

General Information

Symbol

Dmel\vari^R3

Species

D. melanogaster

Name

FlyBase ID

FBal0212964

Feature type

allele

Associated gene

Dmel\vari

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Wu et al., 2007)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: ??T.

(Wu et al., 2007)

Amino acid replacement: Q179term.

(Wu et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:20,790,471..20,790,471 [-]

Nucleotide change:

C20790471T

Reported nucleotide change:

??T

Amino acid change:

Reported amino acid change:

Q179term

(Wu et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage (with vari³²⁷)

(Jeong et al., 2017)

lethal (with Df(2L)TW2)

(Wu et al., 2007)

lethal (with vari^38EFa2)

(Wu et al., 2007)

lethal (with vari³²⁷)

(Wu et al., 2007)

lethal (with vari^03953b)

(Wu et al., 2007)

lethal (with vari^f00033)

(Wu et al., 2007)

Phenotype Manifest In

axon | embryonic stage (with vari³²⁷)

(Jeong et al., 2017)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage (with vari³²⁷)

(Jeong et al., 2017)

presumptive embryonic/larval tracheal system

(Wu et al., 2007)

septate junction

(Wu et al., 2007)

Detailed Description

Statement

Reference

No significant increase in defasciculation defects in intersegmental nerve b motor axons is observed in vari^R3 heterozygous embryos compared to controls.

vari³²⁷/vari^R3 transheterozygous embryos display increased frequency of defasciculation defects in intersegmental nerve b motor axons.

(Jeong et al., 2017)

Mutants show defects in septate junction barrier function (as tested using a dye exclusion assay).

Mutants have strong tracheal defects.

(Wu et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

vari[+]/vari^R3 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of cher^Q1042X

(Jeong et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

vari[+]/vari^R3 is an enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of cher^Q1042X

(Jeong et al., 2017)

vari[+]/vari^R3 is an enhancer of axon | embryonic stage phenotype of cher^Q1042X

(Jeong et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The moderate axon pathfinding defects observed in cher^Q1042X heterozygous embryos are enhanced by combination with a single copy of any of vari^R3.

(Jeong et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

vari^MD109

(Bachmann et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Wu et al., 2007)

vari^R3

(Nguyen et al., 2022, Jeong et al., 2017, Bachmann et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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