FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Chd11
Open Close
General Information
Symbol
Dmel\Chd11
Species
D. melanogaster
Name
FlyBase ID
FBal0212971
Feature type
allele
Associated gene
Dmel\Chd1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Konev et al., 2007)
Progenitor genotype
P{EPgy2}CG9643EY07345
(Konev et al., 2007)
Caused by aberration
Df(2L)Chd11
Cytology
Description

Imprecise excision of the P{EPgy2}CG9643EY07345 insertion, resulting in a deletion that removes part of the CG9643 gene and part of the Chd1 gene (sequences encoding the C-terminal 296 amino acids are deleted).

(Konev et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autism spectrum disorder
      CEA
      (Genç et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  autism spectrum disorder
      is exacerbated by Pdk133
      (Genç et al., 2020)
      is exacerbated by Rim103
      (Genç et al., 2020)
      is exacerbated by wrd104
      (Genç et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 45% of the expected number of Chd11/Df(2L)Exel7014 adults are recovered. None of the embryos laid by Chd11/Df(2L)Exel7014 females mated to wild-type males hatch.

      (Morettini et al., 2011)

      In most embryos derived from Chd11/Df(2L)Exel7014 females, partial decondensation of the sperm chromatin and normal apposition of the parental pronuclei is seen. However, after this, only one pronucleus undergoes mitosis and the other does not.

      (Konev et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)Exel7014/Chd11 is rescued by Chd1WT.Tag:FLAG

      (Morettini et al., 2011)
      Partially rescued by

      Df(2L)Exel7014/Chd11 is partially rescued by Chd1CD.Tag:FLAG

      (Morettini et al., 2011)
      Comments

      Chd1WT.T:Zzzz\FLAG completely rescues and Chd1CD.T:Zzzz\FLAG partially rescues the zygotic lethal phenotype of Chd11/Df(2L)Exel7014. Chd1WT.T:Zzzz\FLAG completely rescues and Chd1CD.T:Zzzz\FLAG partially rescues the maternal effect lethality seen in embryos derived from Chd11/Df(2L)Exel7014 females mated to wild-type males.

      (Morettini et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Chd11
      Chd1[1]
      (Konev et al., 2007)
      chd11
      (Genç et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)