FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Chd12
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General Information
Symbol
Dmel\Chd12
Species
D. melanogaster
Name
FlyBase ID
FBal0212972
Feature type
allele
Associated gene
Dmel\Chd1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Konev et al., 2007)
Progenitor genotype
P{EPgy2}CG9643EY07345
(Konev et al., 2007)
Caused by aberration
Df(2L)Chd12
Cytology
Description

Imprecise excision of the P{EPgy2}CG9643EY07345 insertion, resulting in a deletion that removes the CG9643 and CG3165 genes, part of the CG9641 gene and part of the Chd1 gene (sequences encoding the C-terminal 958 amino acids are deleted).

(Konev et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 29% of the expected number of Chd12/Df(2L)Exel7014 adults are recovered. None of the embryos laid by Chd12/Df(2L)Exel7014 females mated to wild-type males hatch, with most of the embryos arresting development around or shortly after the first two nuclear divisions.

      (Morettini et al., 2011)

      Embryos derived from Chd12/Df(2L)Exel7014 females are haploid and propagation of only the maternal genome is detected in the embryos.

      (Konev et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)Exel7014/Chd12 is rescued by Chd1WT.Tag:FLAG

      (Morettini et al., 2011)

      Df(2L)Exel7014/Chd12 is rescued by Chd1CD.Tag:FLAG

      (Morettini et al., 2011)
      Comments

      Chd1WT.T:Zzzz\FLAG completely rescues and Chd1CD.T:Zzzz\FLAG partially rescues the zygotic lethal phenotype of Chd12/Df(2L)Exel7014. Chd1WT.T:Zzzz\FLAG completely rescues and Chd1CD.T:Zzzz\FLAG partially rescues the maternal effect lethality seen in embryos derived from Chd12/Df(2L)Exel7014 females mated to wild-type males.

      (Morettini et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Chd12
      Chd1[2]
      (Konev et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)