FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\β-SpecS012
Open Close
General Information
Symbol
Dmel\β-SpecS012
Species
D. melanogaster
Name
FlyBase ID
FBal0213006
Feature type
allele
Associated gene
Dmel\β-Spec
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hülsmeier et al., 2007)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C538T.

(Hülsmeier et al., 2007)

The mutation position was reported in nucleotide position with respect to the CDS of the 2291aa isoform.

(Hülsmeier et al., 2007)

Amino acid replacement: ??term.

(Hülsmeier et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:17,661,721..17,661,721 [+]
Nucleotide change:

C17661721T

Reported nucleotide change:

C538T

Amino acid change:

Q180term | beta-Spec-PA; Q180term | beta-Spec-PB; Q180term | beta-Spec-PC

Reported amino acid change:

??term

Comment:

Mutation site reported in terms of nucleotide position with respect to the beta-Spec-RA CDS.

(Hülsmeier et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Stage 14 mutant embryos have axon structures that loop out into the central nervous system cortex at the point where commissural axons normally enter the connectives. The longitudinal connectives are found closer to the midline and appear thinner than normal in stage 16 mutant embryos. In addition, the segmental commissures are not clearly separated and appear slightly fused.

      Specification of the Sema-2b-positive neurons is not affected in β-SpecS012 embryos, however, the structure of the Sema-2b-positive fascicle is severely altered, with the fascicle appearing irregular and being found closer to the central nervous system (CNS) midline than normal. The Sema-2b-positive cell bodies are often shifted towards the CNS midline.

      (Hülsmeier et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      β-SpecS012 is partially rescued by Scer\GAL4elav.PLu/β-SpecUAS.cHa

      (Hülsmeier et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      β-SpecS012
      (Qu et al., 2017, Mazock et al., 2010)
      β-specS012
      (Hülsmeier et al., 2007)
      β-spectrinkusS012
      (Hülsmeier et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)