FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ttm50IE1
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General Information
Symbol
Dmel\ttm50IE1
Species
D. melanogaster
Name
FlyBase ID
FBal0215234
Feature type
allele
Associated gene
Dmel\ttm50
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sugiyama et al., 2007)
Mutagen
ethyl methanesulfonate
(Sugiyama et al., 2007)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Sugiyama et al., 2007)

Amino acid replacement: W197term.

(Sugiyama et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,731,331..2,731,331 [-]
Nucleotide change:

G2731331A

Reported nucleotide change:

G?A

Amino acid change:

W197term | ttm50-PA; W197term | ttm50-PB

Reported amino acid change:

W197term

Comment:

TGG to TAG nonsense mutation in codon Trp197.

(Sugiyama et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae are much smaller than control larvae of the same age and the larvae die as first instar larvae after surviving for approximately 1 week.

      Homozygous clones in the wing contain only one of two cells in contrast to the large control twin spots. Homozygous germline clones cannot be obtained.

      When homozygous clones are induced in polyploid cells in the larval salivary glands, the network of mitochondria in these cells appears less developed than in wild type and there is weakened Mitotracker Red staining, indicating a reduction in mitochondrial activity.

      (Sugiyama et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ttm50IE1
      (Sugiyama et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)