FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TspUAS.AD.cSa
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General Information
Symbol
Dmel\TspUAS.AD.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Subramanian
FlyBase ID
FBal0215333
Feature type
allele
Associated gene
Dmel\Tsp
Associated Insertion(s)
Carried in Construct
P{UAS-Tsp.AD}
Key Links
Transgenic product class
cDNA
(Subramanian et al., 2007)
wild_type
(Subramanian et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Subramanian et al., 2007)
wild_type
(Subramanian et al., 2007)
Mutagen
in vitro construct
(Subramanian et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Tsp.AD}
Cytology
Description

UASt regulatory sequences drive expression of Tsp. The Tsp sequence is derived from the GH27479 and AT07402 ESTs (N-terminal and C-terminal portions of the open reading frame respectively).

(Subramanian et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Tsp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  muscular dystrophy
      modeled by Scgδ840
      (Vanhoutte et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TspScer\UAS.AD.cSa in the embryonic glia that cover all peripheral nerves (under the control of Scer\GAL4repo) does not lead to any somatic muscle pattern defect.

      (Gilsohn and Volk, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ectopic expression of TspScer\UAS.AD.cSa and slowScer\UAS.T:Ivir\HA1 together, under the control of Scer\GAL4repo results in a clear change in the directionality of somatic muscles; in addition, the morphology of the muscle ends is affected, and the edge of the muscles appears pointed. In some cases, the pointed muscle end is directed towards an ectopic site of Tsp and slow accumulation, whereas other muscles are associated with the correct attachment site at the segmental border, but their morphology is abnormally pointed.

      Ectopic expression of TspScer\UAS.AD.cSa and slowScer\UAS.T:Ivir\HA1 together in muscle 12 during its migration, under the control of Scer\GAL45053A results in a morphological alteration of the muscle ends. Overexpression of TspScer\UAS.AD.cSa or slowScer\UAS.T:Ivir\HA1 alone does not affect muscle morphology.

      Third-instar larvae overexpressing both TspScer\UAS.AD.cSa and slowScer\UAS.T:Ivir\HA1 driven by Scer\GAL4Mef2.PR exhibit torn muscles.

      (Gilsohn and Volk, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TspScer\UAS.AD.cSa
      TspUAS.AD.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Subramanian
      Secondary FlyBase IDs
        References (3)