FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\emsUAS.cRa
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General Information
Symbol
Dmel\emsUAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Reichert
FlyBase ID
FBal0215334
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ems
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of an ems cDNA.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

adPN neuroblast clones (induced in the early first instar larva and analysed in the adult brain) that are expressing emsScer\UAS.cRa under the control of Scer\GAL4GH146 show normal cell body projection and axonal projection trajectory, but show marked defects in dendritic targeting, with two types of phenotype being observed. Firstly, the mutant adPNs show ectopic innervation of one or more inappropriate glomeruli; the VA2 glomerulus is ectopically innervated in 100% of clones, VA6 in 78%, VL2 in 78%, VM1 in 11%, VM4 in 44%, DA2 in 78%, DC1 in 44%, DL2 in 89% and DL5 in 22%. Secondly, the mutant adPNs fail to innervate the DL1 glomerulus, which is normally innervated by these neurons in wild type.

The axons of adPN neuroblast clones expressing emsScer\UAS.cRa under the control of Scer\GAL4GH146 (induced in the early larva and analysed in adults) have ectopic terminal arbors between the main arborization area and the secondary arborization area in the lateral horn. Single cell DL1-innervating adPN clones expressing emsScer\UAS.cRa under the control of Scer\GAL4GH146 fail to innervate the DL glomerulus and ectopically innervate the DA2 and DM6 glomeruli and consistently form ectopic terminal branches between the main lateral terminal process and the secondary dorsal terminal process in the lateral horn.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of emsScer\UAS.cRa under the control of Scer\GAL4sca-537.4 significantly rescues the embryonic brain defects and the "open-head" ectoderm defects of ems2 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
emsScer\UAS.cRa
emsUAS.cRa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Reichert
Secondary FlyBase IDs
    References (3)