FlyBase Allele Report: Dmel\Kdm5[UASp.cSa]

General Information

Symbol

Dmel\Kdm5^UASp.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UASp construct a of Secombe

FlyBase ID

FBal0215595

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{UASp-Kdm5.S}

Also Known As

UAS-Lid, UASp-kdm5

Key Links

Transgenic product class

wild_type

(Secombe et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Secombe et al., 2007)

Mutagen

in vitro construct

(Secombe et al., 2007)

Progenitor genotype

Carried in construct

P{UASp-Kdm5.S}

Cytology

Description

UASp regulatory sequences drive expression of lid.

(Secombe et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Kdm5

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Kdm5¹⁴⁰, Scer\GAL4^Mai60

(Drelon et al., 2019)

male sterile, with Kdm5¹⁴⁰, Scer\GAL4^Mai60

(Drelon et al., 2019)

semi-fertile, with Kdm5¹⁴⁰, Scer\GAL4^Ubi.PU

(Drelon et al., 2019)

short lived, with Kdm5¹⁴⁰, Scer\GAL4^Mai60

(Drelon et al., 2019)

short lived, with Kdm5¹⁴⁰, Scer\GAL4^spok.1.45

(Drelon et al., 2019)

sterile, with Kdm5¹⁴⁰, Scer\GAL4^spok.1.45

(Drelon et al., 2019)

viable, with Scer\GAL4^Act.PU

(Li et al., 2010)

visible | adult stage, with Kdm5¹⁴⁰, Scer\GAL4^32B

(Drelon et al., 2019)

visible | adult stage, with Kdm5¹⁴⁰, Scer\GAL4^Mai60

(Drelon et al., 2019)

visible | adult stage, with Kdm5¹⁴⁰, Scer\GAL4^phtm.PO

(Drelon et al., 2019)

visible | adult stage, with Kdm5¹⁴⁰, Scer\GAL4^spok.1.45

(Drelon et al., 2019)

Phenotype Manifest In

wing, with Kdm5¹⁴⁰, Scer\GAL4^32B

(Drelon et al., 2019)

wing, with Kdm5¹⁴⁰, Scer\GAL4^Mai60

(Drelon et al., 2019)

wing, with Kdm5¹⁴⁰, Scer\GAL4^phtm.PO

(Drelon et al., 2019)

wing, with Kdm5¹⁴⁰, Scer\GAL4^spok.1.45

(Drelon et al., 2019)

Detailed Description

Statement

Reference

Expression of lid^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^GMR.PF does not result in a discernible mutant eye phenotype.

(Secombe et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Kdm5^UASp.cSa is an enhancer of visible | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Scer\GAL4^Act.PU/Kdm5^UASp.cSa is an enhancer of decreased size | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Kdm5^UASp.cSa, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Li et al., 2010, Secombe et al., 2007)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Kdm5^UASp.cSa is a non-enhancer of visible phenotype of Cdk4^UAS.cMa, CycD^UAS.cDa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF, Kdm5^UASp.cSa is a non-suppressor of visible phenotype of Cdk4^UAS.cMa, CycD^UAS.cDa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Kdm5^UASp.cSa is an enhancer of eye | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Kdm5^UASp.cSa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Li et al., 2010, Secombe et al., 2007)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Kdm5^UASp.cSa is a non-enhancer of eye phenotype of Cdk4^UAS.cMa, CycD^UAS.cDa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF, Kdm5^UASp.cSa is a non-suppressor of eye phenotype of Cdk4^UAS.cMa, CycD^UAS.cDa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of lid^{Scer\UAS.P\T.cSa} dramatically enhances the rough eye phenotype caused by expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF.

(Secombe et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Kdm5^UASp.cSa rescues Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^da.G32/Kdm5^UASp.cSa rescues Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^RapGAP1-OK6/Kdm5^UASp.cSa rescues Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^Act.PU/Kdm5^UASp.cSa rescues Kdm5¹⁰⁴²⁴

(Li et al., 2010)

Partially rescues

Scer\GAL4^Act5C.PI/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^Ubi.PU/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^32B/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Mai60/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^phtm.PO/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Kdm5^UASp.cSa/Scer\GAL4^T80 partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^spok.1.45/Kdm5^UASp.cSa partially rescues Kdm5¹⁴⁰

(Drelon et al., 2019)

Fails to rescue

Scer\GAL4^Mef2.PR/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^repo/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Belalcazar et al., 2021)

Scer\GAL4^Cg.PA/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Ilp2.PR/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Aug21/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Mef2.PR/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Akh.PL/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^Toll-6-D42/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

Comments

Expression of Kdm5^UASp.cSa under the control of Scer\GAL4^32B, Scer\GAL4^Mai60, Scer\GAL4^spok.1.45 or Scer\GAL4^phm.PO in the Kdm5¹⁴⁰ homozygous background leads to curved-down wings compared to controls.

(Drelon et al., 2019)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Kdm5^UASp.cSa

lid^{Scer\UAS.P\T.cSa}

lid^UASp.cSa

Name Synonyms

Saccharomyces cerevisiae UASp construct a of Secombe

Secondary FlyBase IDs

References (6)

Report Sections