FB2026_02 , released June 18, 2026
Allele: Dmel\swsS985D.UAS
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General Information
Symbol
Dmel\swsS985D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0215613
Feature type
allele
Associated gene
Dmel\sws
Associated Insertion(s)
Carried in Construct
P{UAS-sws.S985D}
Key Links
Transgenic product class
missense_variant
(Muhlig-Versen et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Muhlig-Versen et al., 2005)
Mutagen
in vitro construct
(Muhlig-Versen et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-sws.S985D}
Cytology
Description

UASt regulatory sequences drive expression of mutated sws coding sequence (amino acid replacement S985D).

(Muhlig-Versen et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sws
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of swsS985D.Scer\UAS driven by Scer\GAL4loco.PU does not lead to vacuole formation in 14 day old flies. Scer\GAL4loco.PU>swsS985D.Scer\UAS 14 day old flies show significant defects in a fast phototaxis assay (reduction in percentage transitions towards light).

      (Dutta et al., 2016)

      Expression of swsS985D.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF does not induce any esterase activity nor neuronal degeneration.

      (Muhlig-Versen et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      swsS985D.UAS/Scer\GAL4Appl.G1a partially rescues sws1

      (Bettencourt da Cruz et al., 2008)
      Fails to rescue

      swsS985D.UAS/Scer\GAL4loco.PU fails to rescue swsGD3277

      (Dutta et al., 2016)

      Scer\GAL4elav-C155/swsS985D.UAS fails to rescue sws1

      (Muhlig-Versen et al., 2005)

      Scer\GAL4loco.1.3/swsS985D.UAS fails to rescue sws1

      (Muhlig-Versen et al., 2005)
      Comments

      Co-expression of swsR133A.Scer\UAS (but not swsS985D.Scer\UAS) significantly (partially, not to the same extent as swsScer\UAS.cMa) reduces vacuole formation in lamina cortex and partially rescues phototaxis defects of 14 day old Scer\GAL4loco.PU>swsGD3277 flies.

      (Dutta et al., 2016)

      Expression of swsS985D.Scer\UAS driven pan-neuronally by Scer\GAL4Appl.G1a partially rescues neuropil vacuolization in sws1/sws1 flies (though this rescue is less than is seen with expression of swsScer\UAS.cMa).

      (Bettencourt da Cruz et al., 2008)

      Expression of swsS985D.Scer\UAS in either neurons or glia (under the control of either Scer\GAL4elav-C155 or Scer\GAL4loco.1.3) fails to rescue to wild-type NTE-like activity in sws1 mutants.

      (Muhlig-Versen et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SWSS/D
      (Dutta et al., 2016)
      SWSS985D
      (Dutta et al., 2016)
      swsS985D.Scer\UAS
      swsS985D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)