FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\slprD314Y.KM.UASp
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General Information
Symbol
Dmel\slprD314Y.KM.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0215663
Feature type
allele
Associated gene
Dmel\slpr
Associated Insertion(s)
Carried in Construct
P{UASp-slpr.KD.D314Y.KM}
Also Known As
UAS-slpr-KD
Key Links
Transgenic product class
dominant_negative_variant
(Polaski et al., 2006)
missense_variant
(Polaski et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Polaski et al., 2006)
missense_variant
(Polaski et al., 2006)
Mutagen
in vitro construct
(Polaski et al., 2006)
Progenitor genotype
Carried in construct
P{UASp-slpr.KD.D314Y.KM}
Cytology
Description

Amino acid replacement: D314Y.

(Polaski et al., 2006)

UASp regulatory sequences drive expression of a dominant negative form of slpr. The K to M amino acid replacement is in the VAIK phospho-transfer motif of kinase subdomain II.

(Polaski et al., 2006)

Amino acid replacement: K?M.

(Polaski et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
slpr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of slprD314Y.KM.Scer\UAS.P\T under the control of Scer\GAL4pnr-MD237 results in defects in dorsal closure of the adult thorax (resulting in midline thorax clefts and widening of the space between adjacent dorsocentral bristles).

      (Garlena et al., 2010)

      Expression of slprD314Y.KM.Scer\UAS.P\T under the control of Scer\GAL4arm.PS in an otherwise wild-type background results in very mild embryonic lethality and a low percentage of embryos with a dorsal open phenotype. Expression of slprD314Y.KM.Scer\UAS.P\T under the control of Scer\GAL4arm.PS in embryos derived from slprBS06/+ females significantly increases the percentage of embryonic lethality and severity of cuticle defects.

      Expression of slprD314Y.KM.Scer\UAS.P\T under the control of Scer\GAL4Act5C.PI in females results in maxillary palp and terminalia defects (with truncation of structures posterior to tergite 7).

      (Polaski et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      slprD314Y.KM.UASp/Scer\GAL4GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4GMR.PF, egrGS9830

      (Polaski et al., 2006)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      slprD314Y.KM.UASp/Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, egrGS9830

      (Polaski et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye ablation phenotype seen in adults expressing egrGS9830 under the control of Scer\GAL4GMR.PF is not suppressed by coexpression of slprD314Y.KM.Scer\UAS.P\T under the control of Scer\GAL4GMR.PF.

      (Polaski et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slprD314Y.KM.Scer\UAS.P\T
      slprD314Y.KM.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (2)