FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Prosα627A
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General Information
Symbol
Dmel\Prosα627A
Species
D. melanogaster
Name
FlyBase ID
FBal0215846
Feature type
allele
Associated gene
Dmel\Prosα6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Fluegel et al., 2006)
Progenitor genotype
P{EPgy2}Npc1aEY00751
(Fluegel et al., 2006)
Caused by aberration
Df(2L)NPC127A
Cytology
Description

Imprecise excision of the P{EPgy2} element, resulting in a 1.5kb deletion which removes the first non-coding exon and part of the first intron of NPC1 and removes the first third of the Pros35 transcript.

(Fluegel et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The lethal phase of homozygous larvae is unaffected if they are fed dietary 20-hydroxyecdysone or if they are fed standard food supplemented with 200ng/ml cholesterol.

      (Fluegel et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Prosα6LA1

      (Fluegel et al., 2006)
      Rescued by

      Df(2L)J2/Prosα627A is rescued by Prosα6+t8

      (Fluegel et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pros3527A
      Prosα627A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)